SKIN MICROBIOME The biotic ingredient is easy to formulate


together with other natural ingredients to obtain a product that covers marketing claims such as: sebum reduction; skin shinning; microbiota balance; pore minimization; oily skin treatment; and oily hair treatment. An example of cream formulation with the biotic ingredient is shown in Table 1.


Conclusion Synbiötik Bio Phycoskin is a multifunctional ingredient composed of prebiotic and postbiotic molecules that demonstrate bioactive efficacy for: rebalancing the microbiota by increasing S.epidermidis populations, and reducing S.aureus and C.acnes populations. It inhibits the pathway of the enzyme


5α-reductase and additionally reduce sebum content on the skin and reduce pore size in volunteers. It is a good candidate for skin-targeted


applications such as: skin sebum control; treatment for acne-prone skin; skin microbiota restoration; prevention and repair of acne lesions; facial pore size minimizer and facial skin smoothing.


References 1. de Carvalho CCCR. Marine biofilms: A successful microbial strategy with economic implications. Frontiers in Marine Science. 2018; 5


2. Mühlenbruch M, Grossart H-P, Eigemann F, Voss M. Mini-review: Phytoplankton-derived polysaccharides in the marine environment and their interactions with heterotrophic bacteria. Environmental Microbiology. 2018; 20(8), 2671–2685


3. Gueniche A, Perin, O, Bouslimani A, Landemaine L, Misra N, Cupferman S, Aguilar L, Clavaud C, Chopra T, Khodr A. Advances in Microbiome-Derived Solutions and Methodologies are Founding a New Era in Skin Health and Care. Pathogens. 2022; 11, 121


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6. Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, Mata-Haro V, González-Córdova AF, Vallejo-Cordoba B, Hernández-Mendoza A. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology. 2018; 75, 105–114


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9. Roh M, Han M, Kim D, Chung K. Sebum output as a factor contributing to the size of facial pores: Factors related to enlarged


www.personalcaremagazine.com DAY 0 DAY 28


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Figure 9: Clinical study of the biotic ingredient 1%. Visual pores size reduction and impressive smoothed facial skin after 28 days of usage


TABLE 1: EXAMPLE OF A CREAM FORMULATION OF THE BIOTIC INGREDIENT Phase Ingredients


INCI Water A PC B


Neolone BIO G Carbomer Glycerin Xiliance


Butyrospermum Parkii Butter


Biotic ingredient C Aqua


Glyerin, Ethyl Lauroyl, Arginate HCL Carbomer Glycerin


Cetearyl Wheat Straw Glycosides Massocare GMS MB Glyceryl Stearate Butyrospermum Parkii Butter


Carrylyl/capryl glucoside, water, helianthus annuus seed oil, populus tremuloides bark extract, plankton extract, tocopherol


Genencare OSMS BA Betaine


Hydrolyzed Sodium Hyaluronate Hydrolyzed Sodium Hyaluronate


% w/w


q.s. 100 1.00 0.50 2.00 5.00 2.00


7.00


1.00 4.00 1.00


Properties: Stir until a homogeneous mixture phase A at 75°C. Stir until a homogeneous mixture phase B at 75°C. Disperse phase B in phase A and emulsify using homogenizer until a homogeneous mixture for 10 minutes. Cool to room temperature, stirring constantly. Add phase C at room temperature and emulsify until a homogeneous mixture for five minutes with 3400 rpm


pores. British Journal of Dermatology. 2006; 155(5), 890–894


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function. Experimental Dermatology. 2002; 31(9), 1364–1372


15. Koseki J, Matsumoto T, Matsubara Y, Tsuchiya K, Mizuhara Y, Sekiguchi K, Nishimura H, Watanabe J, Kaneko A, Hattori T, Maemura K, Kase Y. Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus acutissima Cortex. Evid. Based. Complement. Alternat. Med. 2015;2015:853846


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18. Capitanio B, Lora V, Ludovici M, Sinagra JL, Ottaviani M, Mastrofrancesco A, Ardigò M, Camera E. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne. J. Eur. Acad. Dermatol. Venereol. 2014; Dec;28(12):1792-7


May 2024 PERSONAL CARE


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