TRENDING TECHNOLOGIES A Results
Z-Average (d.nm): 170.7 Pdl: 0.182
Intercept: 0.956 Result quality: Good Size Distribution by Intensity
14 12 10 8 6 4 2 0
0.1 1 10 100 Size (d.nm) Record 1:1 1
Figure 3: A: Particle size and PDI, and B: Zeta potential, of Ceramide NP SANIO This can increase the absorption of
transdermal active substances and maximize the effectiveness of active ingredients. On the other hand, niosomes exhibit excellent stability. They do not contain phospholipids, thus
avoiding the oxidation and degradation of phospholipids, and are easy to store. Additionally, niosomes possess good biocompatibility and high tolerance in cosmetic systems.5
1000 10000
400000 300000 200000 100000 0
-100 0
Apparent Zeta Potential (mV) Record 4:1 1
100 200 Size (d.nm) Peak 1: 195.0
Peak 2: 0.000 Peak 3: 0.000
% Intensity:
100.0 0.0 0.0
St Dev (d.nm)
81.94 0.000 0.000
B Results
Zeta Potential (mV): -33.7 Zeta Deviation (mV): 6.88
Conductivity (mS/cm): 0.00775 Result quality: Good
Mean (mV)
Peak 1: -33.7 Peak 2: 0.00 Peak 3: 0.00
Size Distribution by Intensity Area (%)
100.0 0.0 0.0
St Dev (mV)
8.88 0.00 0.00
53
Figures 4A and 4B show transmission
electron microscopy images of AC-EUK-134 SANIO 0.5%. Figure 4A has been stained with phosphotungstic acid (negative staining), and the sample was diluted to a concentration of about 1wt%. After negative staining, the vesicles appear
as white spherical shapes with a particle size of about 30nm, and the size is basically uniform. Figure 4B shows the vesicles in black
spherical shapes without negative staining, and deformable non-ionic surfactants can be observed around the spherical shape. The vesicles remain stable and do not separate after testing, and can be stored for two months under low temperature, high temperature, and light conditions without separation, basic colour change, or precipitation. In addition, the retention rate after two months is still higher than 90%, indicating good stability.
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