SKIN MICROBIOME
Marine biotic ingredient for skin eubiosis
Pilar Águila, Juan Pablo De la Roche, Arancha Barata – MC Actives & Microalgae Solutions ABSTRACT
The marine benthos is a tiny micro- ecosystem on the seafloor and is a key environment that supports early marine life. It is considered the skin of the ocean. Bioactive molecules produced by species in this ecosystem are essential to maintain homeostasis and ensure the survival of all species. Applying blue biotechnology, MC Actives and Microalgae Solutions biomimic marine benthic conditions to produce marine extracts rich in polyphenols and saccharides. Synbiötik Bio Phycoskin® is a biotic ingredient to combat dysbiosis and improve skin integrity in acne-prone skin and oily skin. Its unique blend of prebiotic and postbiotic molecules contributes to: i) reducing skin sebum, ii) improving acne lesions and iii) reducing facial pore size.
The marine benthos is a tiny micro-ecosystem found in the seafloor, a key environment that supports early marine life. All marine larvae, from plankton onward, arrive there to begin a new juvenile stage before adult life. Similarly, our skin is like a microecosystem that supports the life of a community of microorganisms known as our skin microbiota. So, the marine benthos constitutes the ocean’s skin. This place is first colonized by a community
of phytoplankton and bacterial microbiota known as the benthic holobiont. The cells involved in this microecosystem communicate with each other, sharing bioactive molecules. Phytoplankton produces prebiotic saccharides and amino acids, and postbiotic vitamins and polyphenols that are exuded by bacteria.1 These molecules are released from cells
to build an extracellular matrix that provides nourishment to the commensal community, maintains cell adhesion, and provides protection against, for example, temperature and pH fluctuations, UV exposure, salinity changes, nutrient depletion, antimicrobial compounds, and predation.1,2 This extraordinary ecosystem evolves
constantly to achieve eubiosis, the balance between microbial populations, getting success in dispersal migration to other new places. Applying bioengineering, MC Actives and
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Microalgae Solutions biomimic marine benthic conditions to cultivate benthic holobiont in a green lab-grow. This is Phycosphere Biodynamic® technology, an innovative process that allows to produce a marine extract rich in prebiotic and postbiotic molecules with high cosmetic efficacy to combat dysbiosis and improve skin integrity in acne-prone skin and oily-prone skin.
Skin dysbiosis: microbiota diversity related to skin health and disorders The skin microbiota plays an important role in the normal functioning of the skin. It is a beneficial and invisible ecosystem of living microorganisms forming part of our skin’s surface. The bacterial microbiota community protects our skin from external damage, interacting with our skin to ensure a proper functioning. Balanced microbiota population leads to a healthy skin, achieving a condition known as eubiosis; it is essential for our skin health and beauty.3 Exposome factors such as overexposure
to UV radiation, polluting chemicals, and urban lifestyle habits affect overall disrupt this eubiosis stage affecting skin and our microbiota.4
The imbalance of microbial
composition, distribution, and metabolic activity is known as dysbiosis.3 Dysbiosis is observed in many skin
diseases, such as atopic dermatitis, acne, or seborrheic dermatitis. Although there are controversial studies on the positive and negative impact of microbiota species on skin conditions, it is generally considered that certain microbiota species may be related to skin health and skin disorders: ■ Cutibacterium acnes (C. acnes): it represents up to 90% of the microbiome in sebum-rich areas such as the face and the scalp. Loss of diversity in phylotypes is implicated in exacerbated acne, increased lipogenesis, comedones formation, and host inflammation. It also promotes comedogenesis by promoting lipid oxidation, leading to a qualitative change in sebum.5
A predominance
of C. acnes phylotype IA1 is related to a more virulent profile in acne than in normal skin which is related to a hyperseborrheic environment.5 ■ Staphylococcus aureus (
S.aureus): is considered opportunistic pathogenic species. Their populations increase is related to inflammation, irritation (redness) and inch in acne, psoriasis, and chronic open wounds.3 ■ Staphylococcus epidermidis (S.epidermidis): is one of the major representative bacteria of a healthy skin microbiome. It is ubiquitous: present on the whole skin in dry, wet, and sebaceous areas. role in maintaining an effective skin barrier in
May 2024 PERSONAL CARE
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