32 ANTI-AGEING
Boosting NAD+ for skin longevity
Kathrin Nowak, Franziska Wandrey, Fred Zülli – Mibelle Biochemistry ABSTRACT
The cosmetics industry is increasingly focusing on longevity, with a growing demand for maintaining a youthful appearance across all age groups. This article investigates the potential of sunflower sprout active, a product derived from organically grown sunflower sprouts, for promoting skin rejuvenation. In vitro and ex vivo studies have shown that sunflower sprouts can combat ageing processes by elevating NAD+
The beauty industry is increasingly emphasizing the trending concept of longevity to meet the everlasting demand for vital, youthful skin and skin rejuvenation. This emphasis aligns with the historical pursuit for prolonged lifespan, which has driven advances in research related to ageing. In 2013, the classical ‘hallmarks of ageing’
were introduced to define the fundamental biological processes underlying ageing.1
These
mechanisms are universal in all organisms experiencing biological ageing and result in impaired function, the gradual loss of physiological integrity, and ultimately, death. The classical hallmarks of ageing from 2013
include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, mitochondrial dysfunction,
stem cell exhaustion, altered intercellular communication, and deregulated nutrient sensing. As our understanding of the biological mechanisms underlying skin ageing deepens, the concept of skin longevity is likely to become more central in skincare and skin rejuvenation, potentially leading to more targeted and effective treatments.2
The longevity metabolite: NAD+ Growing evidence suggests that the metabolite nicotinamide adenine dinucleotide (NAD+
)
significantly impacts all hallmarks of ageing.3 In recent years, NAD+
has gained substantial
attention, particularly in the dietary supplement industry, as studies have shown a robust correlation between declining NAD+
levels and
accelerated ageing (Figure 1).4 NAD+
10 is a critical coenzyme in energy
metabolism, particularly as it is essential for ATP production. In addition, NAD+
acts as a cofactor
for hundreds of enzymes involved in various cellular processes, which are considerably relevant to all cell types, including skin cells. In skin, inadequate NAD+
5 levels have been 0 40 Age Figure 1: NAD+ declines with age PERSONAL CARE May 2024 80
found to contribute to UV sensitivity, impaired DNA damage response, increased genomic instability, and the promotion of cellular senescence, so-called ‘zombie cells’, which in turn can lead to accelerated skin ageing.5 However, incorporating NAD+
improving mitochondrial function, and increasing collagen density. A subsequent clinical study revealed enhanced skin smoothness and facial lifting potential after application of 2% sunflower sprout active. Furthermore, the treatment noticeably reduced ageing signs, such as wrinkles and nasolabial folds, contributing to a youthful skin appearance. These findings suggest that sunflower sprout active can boost endogenous NAD+
levels, counteract
fundamental ageing processes and optimize cellular processes. Overall, this research highlights the potential of sunflower sprout active in meeting the cosmetics industry’s demand for youthful-looking skin, offering a holistic solution for skin rejuvenation.
Superfood: organic sunflower sprouts Sunflowers (Helianthus annuus), being heliotropic plants, exhibit the unique trait of following the sun’s path across the sky. They symbolize faith, consistency, strength, warmth, and nourishment - qualities inherently linked to the sun. To produce the sunflower sprout active,
sunflower sprouts that are grown indoors in a controlled process, without the use of soil, are used. This method of indoor farming for cultivating organic sunflower sprouts offers numerous benefits. It provides a consistent supply of plant material, unaffected by seasonal changes, soil conditions, and market demand. Moreover, it ensures plant material that is
into cosmetics has
presented challenges due to its instability in formulations and limited penetration into skin cells.
entirely devoid of environmental pollutants and pesticides. It also significantly reduces the water and farmland requirements compared to conventional farming methods. Sprouts are known as superfoods, due to their high concentration of nutrients. During
www.personalcaremagazine.com levels
levels, enhancing DNA repair,
NAD+
(ng/mg protein)
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