ANTI-AGEING A 20 15 10 5 0 28 Days 42 Days 55 ** 60 * 55 -4.9 years -8.2 years ■ Placebo ■ 2% Sunflower sprout active B 65
35 *p<0.01 versus initial condition **p<0.001 versus initial condition and p<0.01 versus placebo
0
4 Time (weeks) Figure 5: Clinical rejuvenation study: sunflower sprout active leads to wrinkle reduction and a more youthful skin appearance
the adverse effects of UV-A radiation on mitochondrial protein damage and collagen density, highlighting its potential to reverse the processes associated with ageing.
Clinical rejuvenation study In vitro and ex vivo efficacy studies have demonstrated that sunflower sprouts can counteract ageing processes, potentially rejuvenating aged skin. Therefore, the clinical study aimed to investigate the impact of sunflower sprout active on skin rejuvenation. The application of 2% sunflower sprout
active significantly improved skin smoothness after 28 and 42 days compared to the initial condition (data not shown). In addition to skin smoothness, assessments were conducted to investigate the facial lifting potential of sunflower sprout active. The smaller the distances between the
reference points at the eye and jaw line region, the more pronounced the lifting effect. Treatment with 2% sunflower sprout active led to a lifting of the jawline region. The length of the measured vertical
lines was significantly reduced by more than 1.5% compared to the placebo (Figure 4A). Images of a volunteer captured with the Visia®-CR demonstrated a visible improvement in ageing signs. The representative pictures
showed a facial reshaping by reducing the crow’s feet wrinkles, the nasolabial fold, and the marionette fold, highlighting that sunflower sprout active visibly and effectively rejuvenates the skin (Figure 4B). The visual improvement in facial ageing
signs was complemented by a quantitative analysis of the impact of sunflower sprout active on wrinkles. The application of sunflower sprout active resulted in a significant reduction in the depth of wrinkles compared to the initial condition, with reductions of 9.2% and 15.3%
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after 28 and 42 days, respectively. After 42 days, the improvement in wrinkle depth was also significant compared to the placebo (Figure 5A). Furthermore, the comparison of the wrinkle
depth measured in this study with a reference dataset revealed that sunflower sprout active made the skin appear on average 4.9 and 8.2 years younger after 28 and 42 days, respectively (Figure 5B). Overall, the findings of the clinical study
demonstrate that sunflower sprout active rejuvenates the skin and contributes to a more youthful-looking appearance.
■ Hallmarks that are addressed by sunflower sprout active
Conclusion The sunflower sprout active, derived from organically cultivated sunflower sprouts through sustainable indoor farming, has been shown to naturally enhance endogenous NAD+
levels. The
extract from the sunflower sprouts invigorates mitochondria, promotes DNA repair, and optimizes cellular processes. The data from prior research, in conjunction with the findings from this study, have unveiled that sunflower sprout active targets at least five of the classical hallmarks of ageing, the very essence of age-related processes (Figure 6). Moreover, clinical findings have revealed
that sunflower sprout active promotes skin longevity by visibly rejuvenating the skin, potentially taking eight years off one’s visual age appearance. With its holistic approach to skin rejuvenation, this active ingredient meets the enduring demand of the cosmetic industry for vital, youthful-looking skin.
References 1.
6
PC López-Otín C, Blasco MA, Partridge L,
Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-217 2. Jin S, Li K, Zong X, Eun S, Morimoto N, Guo S. Hallmarks of Skin Aging: Update. Aging Dis. 2023;14(6):2167-76 3. Lautrup S, Hou Y, Fang EF, Bohr VA. Roles of NAD(+) in Health and Aging. Cold Spring Harb. Perspect. Med. 2024;14(1)
4. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-41
5. Benavente CA, Jacobson MK, Jacobson EL. NAD in skin: therapeutic approaches for niacin. Curr. Pharm. Des. 2009;15(1):29-38
Figure 6: Sunflower sprout active tackles the hallmarks of ageing
6. Guo S, Ge Y, Na Jom K. A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.). Chem. Cent. J. 2017;11(1):95
May 2024 PERSONAL CARE
Improvement in wrinkle depth compared to initial conditions in %
Skin age in relation to wrinkle depth
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