TRENDING TECHNOLOGIES


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C.acnes 24h ■ C.xerosis 24h ■ S.aureus 24h ■ C.acnes 48h ■ C.xerosis 48h ■ S.aureus 48h ■


1.00E+12 1.00E+11 1.00E+11 1.00E+10


1.00E+09 1.00E+08 1.00E+07 1.00E+06 1.00E+05 1.00E+04


1.50% 1.00% Phenoxyethanol 0.50% Minimum media Optimum media


Figure 2: Antibacterial effect of sample 1-3 after 24 and 48 hours after inoculation


environmental conditions, and extraction methods. Additionally, ongoing research may lead to the discovery of new bioactive compounds in mānuka leaves, further expanding our understanding of its medicinal potential.


β-Caryophyllene - the powerhouse compound One standout bioactive compound found in mānuka leaves is β-caryophyllene, a sesquiterpene commonly present in various plants, including cannabis and black pepper. What sets mānuka apart is the significant concentration of β-caryophyllene in its leaves. This compound has gained attention for


its anti-inflammatory properties, making it a perfect candidate for the development of natural anti-inflammatory cosmetic actives.


The mechanism of β-Caryophyllene in inflammation β-caryophyllene exerts its anti-inflammatory effects through interaction with the endocannabinoid system (ECS). Unlike other cannabinoids found in cannabis, β-caryophyllene selectively binds to cannabinoid receptor type 2 (CB2). The activation of CB2 receptors modulates


120 90 60 30 0


Mānuka Leaf Extract MānukaDerMX Leaf Extract


Figure 3: Total antioxidant capacity result www.personalcaremagazine.com Vitamin C 15% (w/v)


immune responses and inflammation, offering a targeted approach to managing inflammatory conditions.


Synergistic effects of other bioactive compounds While β-caryophyllene takes the spotlight, mānuka leaves boast a plethora of other bioactive compounds that work synergistically to enhance its medicinal properties. These include flavonoids, tannins, and polyphenols, each contributing to the overall anti-inflammatory and antioxidant potential of the plant. Flavonoids, for instance, have been


shown to inhibit inflammatory pathways and reduce oxidative stress. Tannins exhibit anti- inflammatory effects by modulating immune responses. The combined action of these compounds in mānuka leaves showcases the complexity and effectiveness of a whole plant botanical extraction compared to isolated compounds.


Mānuka leaf extracts in inflammatory conditions The potential applications of mānuka leaf extracts in managing inflammatory conditions and its broad spectrum anti-microbial


67.7 66.9 66.1 65.3 64.5


Mānuka Leaf Extract


Figure 4: Total polyphenol (Maximum, Average, Minimum) concentration result


May 2024 PERSONAL CARE


properties are diverse. Researchers are exploring the use of these extracts in conditions such as rheumatoid arthritis, inflammatory bowel disease, and dermatological disorders. The natural and holistic approach of whole


plant mānuka leaf extracts presents an appealing alternative to conventional anti-inflammatory medications with fewer side effects. The synergistic action of other bioactive


compounds further enhances the therapeutic potential of mānuka leaf extracts. As research continues to unfold, mānuka


leaves could become a cornerstone in the development of novel anti-microbial and anti-inflammatory cosmetic ingredients. The integration of traditional knowledge with modern scientific exploration highlights the importance of preserving and harnessing the medicinal properties of nature. Mānuka, once primarily known for its honey,


is now emerging as a holistic healing resource, with its leaves holding the key to a new era of highly effective bioactives.


Mānuka leaf extract & the skin microbiome The human skin microbiome, comprising trillions of microorganisms, plays a crucial


Trolox Concentration (ug/ml)


Concentration of bacterium in CFU/L


Polyphenol Concentration (ug/ml)


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