82 NATURALS
effect on most subjects. Skin type is not a stationary condition but it is a dynamic condition affected by seasonal changes. In addition, autumn and winter season made the skin of the human cheek which sebum was less than that of forehead more and drier.31 Excessive sebum production can lead We finally investigated
to enlarged pores.32
the improvement effect of LC on the number of large pores. With continued use for four weeks, LC also reduces skin pores compared to vehicle. This shows that LC can improve skin condition by inhibiting lipid synthesis, reducing sebum secretion, and reducing the number of pores that can be identified by VISIA. Although the study design has certain limitations, including a relatively small participant size and potential influence from seasonal changes, the findings indicate that the topical use of Lotus corniculatus seed extract (Smopore LC) yields clinical benefits in reducing sebum production and enhancing skin pore appearance for individuals with oily skin.
The underlying mechanism appears to be
associated with the LA-PPARγ and DHT-AR signaling pathways involved in lipogenesis. Notably, the unique active components identified in this extract may include 5’-o-rhamnosyluridine and quercitrin.
Author acknowledgement We would like to thank Dr Christos C. Zouboulis for kindly providing SZ95 sebocytes.
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PERSONAL CARE March 2024 PC
Figure 5: Skin pores improvement of LC in oily skin. A: In a randomized controlled blinded half-side comparison study, decrease in the skin pores was observed by VISIA after four weeks of topical application of the serum contained 5% LC. B: The case of individual subject #8 by VISIA is shown
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www.personalcaremagazine.com A
150 100 50 0
B Vehicle W0 Vehicle W4 5% LC W0 5% LC W4 -12.04% Vehicle ■ 5% LC ■
W4 T0h
Δ Pores
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