12 NEWS
US university study ‘discovers microbiome links to skin ageing’
A study by researchers at the Centre for Microbiome Innovation (CMI) at the University of California San Diego (UC San Diego) and L’Oréal Research and Innovation has revealed how the skin microbiome could be associated with wrinkles and skin health.
The findings published in
Frontiers in Aging detail what is claimed to be the first study to isolate microbes associated specifically with signs of skin ageing and skin health, rather than chronological age. Two notable trends emerged
from the paper entitled A multi- study analysis enables identification of potential microbial features associated with skin aging signs. Firstly, it found a positive association between skin microbiome diversity and lateral cantonal lines (crow’s feet wrinkles), which are generally viewed as one of the key signs of skin ageing. Secondly, a negative correlation
was observed between microbiome diversity and transepidermal water loss, which is the amount of
apart the microbes that are associated with these types of ageing signs for skin, like crow’s feet wrinkles, from those that are associated with simply age as a chronological number.” Future paths of investigation
moisture that evaporates through the skin. Combining CMI’s data analysis
expertise with L’Oréal’s knowledge in skin health assessment, the study examined data collected during 13 studies that L’Oréal had carried out in the past, consisting of 16S rRNA amplicon sequence data and corresponding skin clinical data for over 650 female participants, aged 18-70.
While each of the studies included in the analysis had focused on one particular area of interest—for example, crow’s feet wrinkles or moisture loss—this
multi-study analysis collated the data to search for trends related to specific microbes while accounting for other variables, such as age. “Our skin changes
physiologically with age; for example, we gain wrinkles and our skin gets drier. But there is variation in what this looks like in people - you’ve probably noticed that there are some people who have younger or older looking skin than many others their age,” said corresponding author Se Jin Song, CMI Director of Research. “Using advanced statistical
methods, we were able to tease
the team has suggested include metabolomics work to discover chemical biomarkers related to skin ageing, as well as meta- transcriptomics research into potential targets for genetic engineering. Research into other layers of the skin has also been considered. “By confirming a link between
the microbiome and skin health, we’ve laid the groundwork for further studies that discover specific microbiome biomarkers related to skin ageing, and, one day, show how to modify them to generate novel and highly targeted recommendations for skin health,” said co-author Rob Knight, CMI Faculty Director and Professor of Pediatrics, Bioengineering, Computer Science & Engineering and Data Science at UC San Diego.
Amorepacific ‘finds skin health benefits from ginseng’
Korean cosmetics powerhouse Amorepacific has published research that reveals a potential improvement in lymphatic activation and skin health through fermented ginseng ingredients. The research, in collaboration with
the School of Mechanical Engineering at Korea University, could provide new possibilities for skin ageing and homeostasis maintenance using Lab-on-a-chip technology. A paper, The advanced
3D lymphatic system for assaying the human cutaneous lymphangiogenesis in the microfluidic platform, has been published in ‘NPG Asia Materials,’ an international journal by the scientific journal Nature. The lymphatic system, a crucial
organ for maintaining homeostasis and activating the immune system through circulation and waste removal, plays a significant role in skin health. Disruption in lymphatic
circulation within the skin can lead PERSONAL CARE March 2024 Lymphanax™ Skin
of substances applied to the skin on lymphatic formation and check molecular biological changes. Amorepacific’s Lymphanax,
Lymph (Human Skin Structure)
to problems and accelerated ageing. However, directly observing
changes in living tissue’s most profound lymphatic systems has been challenging. The R&I Centre at Amorepacific
and Professor Chung Seok’s laboratory at the School of Mechanical Engineering, Korea University, have been conducting extensive research to elucidate the interdependent relationship between lymph circulation and skin. The joint research team utilized
state-of-the-art human skin structure replication technology and Lab-on-a-chip systems, a type of
(Skin-lymph-on-a-chip) Fresh Ginseng
organoid technology enabling the observation of networks between various cells. In this research, they cultivated human-derived skin cells and 3D lymphatic forming cells under optimal conditions to create a Skin- Lymph-on-a-chip. This enabled the replication of
networks between human skin and lymphatic vessels, visually observing the impact of substances applied to the skin on lymphatic formation and activity. This system, which mimics the
network between human skin and lymphatics, can observe the impact
made from ginseng naturally fermented for 500 hours and rich in the lymph-activating component Gypenoside XVII, has been proven to strengthen the skin barrier and aid internal skin circulation, as observed in the Skin-Lymph-on-a- chip system. The joint research team
concluded that Lymphanax, which is used as an ingredient in its Sulwhasoo brand, aids in forming healthy lymphatic vessels within the skin and strengthens the skin barrier through additional analysis, including AI algorithms. Suh Byung-fhy, CTO of
Amorepacific’s R&I Centre, said: “This research has, for the first time, clarified the correlation between human skin and lymphatic vessels, and particularly, it is meaningful as it confirms the efficacy of ginseng ingredients.
www.personalcaremagazine.com
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