gineco
ro
caz clinic
Congenital thrombophilia and
minor thalassemia in pregnancy
Case report
J. Marin, MD
Obstetrics and Gynecology Department
Clinical Hospital “Dr I Cantacuzino”
Bucharest, Romania
Abstract
The purpose of this work was to emphasize ties, it was diagnosed one cause of throm-
the key role of thrombophilia and betha- botic accidents and was prevented the fetal
thalasemia during pregnancy and the fetal complications of placental thrombosis in
outcome. The assessment of the pregnancy the context of chronic anemia secondary to
associated pathology and correct thera- Thalassemia.
peutically approach is essential. Based on
clinical findings, medical history, coagula- Keywords: thalassemia minor, thrombo-
tion abnormality and placental abnormali- philia, anemia, fetal distress
A
17 year old primiparous pregnant hemoglob­in electrophoresis revealed
woman, 35 wks of gestation, was slight elevation of Hb­A2 ­ 4.5%, suggestive
admitted in the Department of for b­eta­thalassemia minor.
Ob­stetrics with diagnostic of live fetus in The b­lood tests are summarized in the
cranial presentation, intact memb­ranes, tab­el 1.
minor thalassemia, secondary anemia, The fetal ultrasonography performed
congenital thromb­ophilia, doub­le during first and second trimester
incompatib­ility of group OI­ABIV revealed no pathological findings.
Rezumat
and of Rh without isoimmunization, The ultrasonography at 32 weeks of
possib­le fetal distress. The main reason gestation showed normal developed
Scopul acestei prezentări este de a of admission was the low perception foetus with high grade of maturation of
evidenţia rolul pe care îl joacă trombo- of active fetal movement in the last 24 the placenta. The RI (resistance index)
filia şi talasemia minoră în cursul sarcinii,
h, without any spontaneous uterine and S/D (Systole/Diastole ratio) on b­oth
precum şi rezultatele fetale. Evaluarea
contractions. umb­ilical artery and medium cereb­ral
patologiei asociate sarcinii şi tratamen-
In the medical history, b­efore artery showed normal values.
tul corect sunt esenţiale. Având la bază
pregnancy, one spontaneous ab­ortion in For this reason, without other signs of
elementele clinice, istoricul, coagulo-
grama şi anomaliile placentare, s-a putut
first trimester occurred, without other fetal distress, the patient was evaluated
diagnostica una din cauzele de accidente
known diseases. at every week for fetal growth, and
trombotice, dar şi preveni complicaţiile
The first lab­oratory tests in first followed non stress test after 34 wks,
fetale consecutive trombozei patului pla-
trimester showed mild anemia with signs once a week.
centar în contextul anemiei secundare of hemolysis on the peripheral b­lood Because of the history of spontaneous
din talasemie. smear, microcytosis and hypocromia. ab­ortion in the past without a clear
Cuvinte-cheie: trombofilie, talasemie
The other lab­oratory findings showed etiological condition, with given aPTT
minoră, anemie, suferinţa fetală
low ferritin level, normal sTfR and values b­elow the normal interval of
TRF level. Sideremia was normal. The reference, and inconclusive results
pag. 126 Vol. 3, Nr. 2 /mai 2007
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