96 NATURALS
Fading of dark spot 1% NIXALIN™ Unified tone
Skin more beautiful Texture improved Softer skin
Figure 4: Anti-imperfection efficacy on dry, sensitive and weakened skin
skin (80%) compared with the placebo (60%), confirming long term efficacy (Figure 2).
Visible effect on skin imperfections Conducted on 50 volunteers, a consumer test confirmed the advantage of using betulin to improve skin texture and to reduce skin imperfections (Figure 4) of dry, sensitive, and weakened skin. These results were supplemented by those of the clinical test mentioned above: after 28 days, a significant majority of participants observed more even skin complexion (85%).
The added advantage: upcycling industry residue As betulin is extracted from the bark of white birch, it holds another, more discreet advantage: the possibility to upcycle industry residue. There is an entire industry in Canada
dedicated to manufacturing items from the white birch wood because it is non-toxic and tasteless: cooking utensils made of wood, medical tongue depressors, coffee stirrers etc. are often made of this material. In Canada, white birch is selectively and
carefully harvested according to a strict regulatory framework that governs the country’s entire forest inventory. The bark of white birch is typically buried or used as an energy source by the forestry industry. It is an undeniable advantage for a
business to have access to large quantities of good quality industry waste with no real commercial value. White birch bark is sourced from a sustainable Canadian industry, and the external bark is mechanically separated from the inner bark and wood remnants, which can then be turned to mulch for horticultural purposes.
The external bark is where the tree stores the betulin, and there exists a new, unique technology to extract it to greater than 98% purity for use in the dermo-cosmetic industry. This new technology uses only non-
toxic, Class-III solvents, and allows complete control over the morphology and granulometry of the particles to ensure optimal dispersibility in an oily phase or a final emulsion.
Conclusion Triterpenes have long been used as a therapeutic agent in various pharmacological formulations. Today, Terlys offers the opportunity to use triterpenes as active ingredients for the cosmetics and personal care industries, with a commitment to green sustainability. The ingredient Nixalin™ contains over 98% betulin, and provides multiple functions for a complete return to homeostasis of the skin barrier. With high and fast performance in skin regeneration and restoration, this active ingredient helps to reduce the consequences of the repetitive barrier gestures on the skin.
References 1. Patocka J. Journal of Applied Biomedicine. 2003, 1, 7-12
2. Agra L. et al. J Dermatol Treat. 2015, 26:465- 470
3. Shaker D et al. Scientia Pharmaceutica. 2019, 87, 17
4. Martini M. Éditions médicales internationals. 2003, 401p
5. Farage MA. Front. Med. 2019, 6:98 6. Misery L et al. J. Eur. Acad. Dermatol. Venereol. 2016, 30(1): 2-8
PERSONAL CARE October 2022
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