72 HYGIENE CONTROL KALIBIOME
12 10 8 6 4 2 0
Kalibiome Figure 4: Surface coverage of
S.aureus after 280 minutes of continuous infusion of medium and Kalibiome, and control
during allergic and acute inflammations), while increasing by 300% versus control the expression of the physiological short TSLP, cytokine physiologically expressed during the mid-anagen phase and promoting hair follicle tissues regeneration. Not only does the activity on TSLP represent
a biological mechanism enabling to balance the anagen/telogen phases throughout the hair life cycle, it also supports the process of hair regeneration following traumas or wounds. As for the free radical scavenging action,
the tests analyzed the mitochondrial ROS (O2 superoxide) reduction in living cells; Kalibiome
postbiotics reduced more effectively than glutathione the superoxide radical found in the cells subject to oxidation, outperforming it at every dosage analyzed (Figure 3). The oxidative stress decrease contributes
to the immune system modulation activity, as it downregulates the activation of pathways involving the induction of lipid peroxidation, membrane disruption, protein denaturation that leads to nucleic acids damages, mitochondrial damage and oxidative explosion. Proper protection against free radicals represents one of the main mechanisms of last generation products for anti-hair loss and hair anti-ageing. The interference with pathogens biofilm
formation is shown in Figure 4. Kalibiome postbiotics inhibit the formation of
S.aureus biofilm, germ involved in inflammation diseases and frequently occurring in cases of androgenetic alopecia, whose proteases, antigens and toxins amplify inflammation and induce skin barrier function alterations. Kalibiome showed significant bacteriostatic action by totally inhibiting the growth of Staphyloccocus aureus following 280 minutes according to the previously mentioned assessment procedure.
Conclusion Kalibiome postbiotics are a complex of biotech actives developed through a patented fermentation technique that enables to obtain with standardised reproducibility bacterial active metabolites with proven safety and with patented composition. Their combined immune system
PERSONAL CARE October 2022
modulation, refined cytokine and chemokines regulation - specifically those involved in the regularisation of the hair follicle anagen/ telogen phases equilibrium - together with their bacteriostatic action on pathogens, microbiome balancing and free-radical scavenging properties can be key mechanisms to support daily routine scalp microbiome treatments, as well as anti-hair loss and hair anti-ageing applications, with potential expansion to anti-greying and dandruff support treatment. Kalibiome postbiotics represent the ideal
ingredients in all formulations developed to strengthen the hair and make it healthier and more beautiful. Their powdery and preservative-free nature, their hydro-solubility and lack of interaction with cosmetics preservatives, makes them suitable for several applications, including glycolic and hydro- alcoholic lotions, shampoos (traditional and dry), mousse, conditioner, masks, sprays and gels.
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2. Xu Z, Wang Z, Yuan C, Liu X, Yang F, Wang T et al. Dandruff is associated with the conjoined interactions between host and microorganisms. Sci. Rep. 2016; 6:24877. doi: 10.1038/srep24877
3. Polak-Witka K, Rudnicka L, Blume-Peytavi U, Vogt A. The role of the microbiome in scalp hair follicle biology and disease. Experimental Dermatology. March 2019
4. Brandwein M, Steinberg D, Meshner S. Microbial biofilms and the human skin microbiome. NPJ Biofilms Microbiomes. 2016; 2:3. doi: 10.1038/s41522-016-0004-z
5. Park HK, Ha MH, Park SG, Kim MN, Kim BJ, Kim W. Characterization of the fungal microbiota (mycobiome) in healthy and dandruff-afflicted human scalps. PLoS ONE. 2012; 7:e32847. doi: 10.1371/journal. pone.0032847
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7. Chang KR, Tay AS, Li C, Ng AH, Wang J, Suri BK et al. Whole metagenome profiling reveals skin microbiomedependent susceptibility to atopic dermatitis flare. Nat. Microbiol. 2016; 1:16106. doi: 10.1038/nmicrobiol.2016.106
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11. M Trüeb RM. Oxidative Stress in Ageing of Hair. International Journal of Trichology. Jan-Jun 2009; Vol. 1, Issue 1
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13. Rinaldi F, Trink A, Pinto D. Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study. Dermatol. Ther. 2020; 10:483–493
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