HAIR STYLING
Crinipan PMC green performed equal to piroctone olamine (in vivo shampoo study). Both products significantly reduced dandruff vs. baseline on greasy scalp after 28 days.
very large quantity of dandruff
5 4 3 2 1
No dandruff 0 ADHERENT DANDRUFF 2.75 3.08 1.90 2.08 NON-ADHERENT DANDRUFF 2.582.56 1.81 1.56 D0 D28 Crinipan PMC green ■ Piroctone Olamine ■
Figure 1: Shampoo study. Mean visual dandruff scores determined by professional evaluators in Poland on a scale from zero to five for adherent/non-adherent dandruff, and on a scale from zero to ten for total dandruff as a sum with 21 subjects
adherent dandruff score was observed at the end of the application phase (D28) versus baseline (D0) for both groups (propanediol caprylate p=0.0004; piroctone olamine p=0.0056). Similarly, the reduction in the non-
adherent dandruff score at D28 versus D0 was also statistically significant for both studied shampoos (propandiol caprylate p=0.0050; piroctone olamine p=0.0028). While no significant difference between the two groups was identified, the total dandruff score was reduced from 5.33 to 3.71 (p=0.0002) in the propanediol caprylate group, and from 5.64 to 3.64 (p=0.0032) in the piroctone olamine group.
Effectiveness of propanediol caprylate in combination with piroctone olamine A general aim of the cosmetic industry for superior effectiveness of anti-dandruff applications can also be concluded from the new limit of 2% climbazole in rinse- off shampoo. This regulatory limit is the ultimate result of a request from shampoo manufacturers for higher use levels.
TABLE 1 INCI
Sodium Laureth Sulfate. Lauryl Glycoside
Citric Acid
Disodium EDTA Water (Aqua)
Polyquaternium-10 Sodium Benzoate Phenoxyethanol
Cocoamidopropyl Betaine
Propanediol Caprylate (Crinipan PMC green)
Piroctone Olamine
Formula 1 17
0.15 0.1
76.05 0.2 0.5 0.5 5
0.5 -
Formula 2 17
0.15 0.1
76.05 0.2 0.5 0.5 5
- 0.5
Table 1: pH 5.5 simplified and unperfumed shampoo formulations used for the in vivo comparison study propanediol caprylate vs. piroctone olamine
www.personalcaremagazine.com The European safety evaluation process by
the SCCS had first concluded that increasing shampoo use levels to 2% - and keeping the generic use level of 0.5% in parallel - would not work out in their worst case-aggregate exposure scenario; thus anti-dandruff shampoos were prioritized for the 2% limit, while even lower use levels for other applications were implemented. An augmented use level of 0.75% piroctone
olamine was reported to be particularly effective in a recent article by Clariant.14 Combining different ingredients, as described before, is also an attempt to achieve better efficacy. Considering all these factors, we aimed for
another randomized, blind study comparing a simplified standard shampoo using 0.75% piroctone olamine as positive control versus a second shampoo containing 0.5% propanediol caprylate plus 0.25% piroctone olamine. Either piroctone olamine or the combination
of propanediol caprylate and piroctone olamine were added to two separate, but identical clear and unperfumed sodium laureth sulfate shampoo bases at the respective use levels (Table 2). Forty preselected volunteers with mixed dandruff conditions, half of them with greasy and the other half with dry scalp, followed a 14-day, pre-conditioning procedure in which they were only allowed to wash their hair with a standardized neutral market shampoo without active, previously provided by the external institute. After the conditioning phase, 20 subjects
(ten with greasy scalp, ten with dry scalp) applied the piroctone olamine (positive control) shampoo, and the remaining 20 subjects (with identical split greasy/dry scalp) applied the test shampoo with a combination of propanediol caprylate/piroctone olamine. The test shampoos were applied at least three times a week. The visual dandruff score was rated in the
test institute before the first application (D0), after 14 (D14), 28 (D28) and 42 days (D42) of application. An additional rating was carried out after a total of 63 days (D63), at the end of a wash out period of 3 subsequent weeks, in
October 2022 PERSONAL CARE D0 D28
8 6 4 2 0
TOTAL DANDRUFF 5.64 5.33 3 3.64.71
65
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108
