NEWS
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Gattefossé co-develops 3D method to improve in vitro testing
French companies Gattefossé and CTIBiotech have developed what is claimed to be the world’s first bioimpedance 3D bioprinted skin chips to link cosmetics lab testing to humans. The developed model is said to allow fast and
non-invasive measurement of sebum production and improve the predictivity of in vitro tests of sebum- regulating ingredients. Sebum is a complex lipids mixture secreted by
sebocytes and deposited in stratum corneum for helping to the skin barrier function. Disruption of sebum production leads to common skin diseases, including acne or atopic dermatitis; it also contributes to the development of oily or dry skin and impacts both appearance and beauty of the skin. Solutions to develop more efficient cosmetics
still require more predictive testing ranging from lab data to humans. Success of lab-to-donor data is not easy and quite often fails because of no proper translational readouts. Gattefossé and CTIBiotech therefore joined
forces to develop a relevant 3D bio printed model integrating sebocytes for measuring non-invasive parameters in vitro as on real humans while at the same time giving laboratory readouts.
PFAS breakthrough claimed by US uni
Researchers at Northwestern University in the US have claimed a breakthrough in breaking down perfluoroalkyl and polyfluoroalkyl substances (PFAS). Chemists at the Illinois institute have
developed a process to that cause these two major classes of PFAS compounds, to fall apart using low temperatures and inexpensive, common reagents. At one end of the molecule, there is a
charged group that often contains charged oxygen atoms that was targeted by heating the PFAS in dimethyl sulfoxide with sodium hydroxide. The process decapitated the group, leaving behind a reactive tail. “That triggered all these reactions, and
it started spitting out fluorine atoms from these compounds to form fluoride,” said Northwestern’s Professor William Dichtel, who led the ‘Low-temperature mineralization of perfluorocarboxylic acids’ study.
Bioimpedance (also known as bioelectrical
impedance analysis) has been widely used to monitor personal health and body composition and adjust diet and lifestyles accordingly. Using connected scales, Gattefossé and
CTIBiotech used bioimpedance to evaluate changes in the local environment of a 3D skin model integrating sebocytes. Measurement of such a non-invasive
electrical activity allowed us to follow in real-time the sebum production, in addition to laboratory readouts dealing with cellular, matrix and tissue development. “Bioimpedance has long been used in our
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bathroom scales and by dieticians to understand general body composition. Application of this to skin is a natural advance on this, but the real innovation comes from developing real-time analysis for oil changes,” said Professor Colin McGuckin, president and chief scientific officer of CTIBiotech.
Credit: Michigan Department of Environment, Great Lakes and Energy
www.personalcaremagazine.com
October 2022 PERSONAL CARE
credit: CTI Biotech
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