92 NATURALS A 0.0
-2.0 -4.0 -6.0 -8.0
-10.0 -12.0 -14.0 -16.0 -18.0 -20.0
-11.2 Firmness Variation 5.5 * B
8.0 7.0 6.0 5.0 4.0 3.0 2.0 1.0 0.0
Active Cream Placebo 6.8
Elasticity Variation *
1.0 Active Cream Placebo
Figure 5: Skin firmness (5A) and elasticity (5B) % change during the study. Mean values of all the subjects (n=22). Statistical comparison between the two products (*: p<0,05; N.S.: Non-significant)
A
25.0 20.0 15.0 10.0 5.0 0.0
Skin Hydration Variation 22.2 * 14.3 B
1.5 1.0 0.5 0.0
-0.5 -1.0 -1.5 -2.0
Active Cream Placebo Active Cream 1.1
Skin Luminocity (L*) *
-1.5 Placebo
Figure 6: Skin hydration (6A) and luminance (L*) (6B)as % change. Mean values of all the subjects (n=22). Statistical comparison between the two products (*: p<0,05; N.S.: Non-significant)
expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol. Lett. 2006;106(1):72–81. doi:10.1016/j. imlet.2006.04.012
7. Lu Y, Feng Y, Liu D, Zhang Z, Gao K, Zhang W, Tang H. Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling. Cell Physiol. Biochem. 2018;47(3):1193-1206. doi: 10.1159/000490216
8. Tavakkoli A, Mahdian V, Razavi BM, Hosseinzadeh H. Review on clinical trials of black seed (Nigella sativa) and its active constituent, thymoquinone. J. Pharmacopuncture. 2017;20(3):179-193. doi: 10.3831/KPI.2017.20.021
9. Ghosheh OA, Houdi AA, Crooks PA. High- performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L). J. Pharm. Biomed. Anal. 1999;19:757–762. doi: 10.1016/s0731- 7085(98)00300-8
10. Cheikh-Rouhou S, Besbes S, Hentati B et al. Nigella sativa L: Chemical composition and physicochemical characteristics of lipid fraction. Food. Chem. 2007;101:673–681
11. Lutterodt H, Luther M, Slavin M et al. Fatty acid profile, thymoquinone content, oxidative stability, and antioxidant properties of cold- pressed black cumin seed oils. LWTFood. Sci. Technol. 2010;43:1409–1413
12. Yarnell E, Abascal K. Nigella sativa: holy herb of the Middle East. Altern. Compl. Therap. 2011; 17(2):99-105
PERSONAL CARE October 2022
Figure 7: Effect of cream containing 3% B’utyQuin on general skin appearance over a 28-day study.)
13. Padhye S, Banerjee S, Ahmad Aet al. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6:495-510
14. Gharby S, Harhar H, Guillaume D et al. Chemical investigation of Nigella sativa L. seed oil in Morocco. J. Saudi Soc. Agric. Sci. 2015;14:172-177
15. Tembhurne SV, Feroz S, Sakarkar DM. A review on the therapeutic potential ofNigella sativa (kalonji) seeds. J. Med. Plants Res. 2014;8:166-167
16. Ahmad A, Husain A, Mujeeb M et al. A review on therapeutic potential ofNigella sativa: A miracle herb. Asian Pac. J. Trop. Biomed. 2013;3:337-352. doi:10.1016/S2221- 1691(13)60075-1
D0 D28
17. Shen HH, Peterson SJ, Bellner L et al. Cold- pressed Nigella sativa oil standardized to 3% thymoquinone potentiates omega-3 protection against obesity-induced oxidative stress, inflammation, and markers of insulin resistance, accompanied with conversion of white to beige fat in mice. Antioxidants. 2020;9:489; doi:10.3390/antiox9060489
18. Unpublished Research. Stimulation Of mitochondrial functions expressed in ATP production and attenuation of h2o2 induced mitochondrial dysfunction. The Skin Research Institute. Dead Sea & Arava Science Center, Dead Sea, Israel. January 2021
19. Ortega SP, Chouchani ET, Boudina S. Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes. Adipocyte. 2017;6(1):56-61. doi:10.1080/2162394 5.2016.1273298
20. Seale P, Kajimura S, Yang Wet al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007;6(1):38-54. doi: 10.1016/j. cmet.2007.06.001
21. Tezze C, Romanello V, Sandri M. FGF21 as modulator of metabolism in health and disease. Front Physiol. 2019;10:419. doi:10.3389/ fphys.2019.00419
22. Piantadosi CA, Carraway MS, Babiker A, Suliman HB. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res. 2008;103(11):1232-1240. doi: 10.1161/
01.RES.0000338597.71702.ad
www.personalcaremagazine.com
% Change D28-D0(%)
% Change D28-D(%)
% Change D28-D0(%)
% Change D28-D0(%)
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108
