94 MALE GROOMING


their skin density. Based on these findings, Peptovitae Matrix at 2% was shown to improve signs of skin photoageing by demonstrating a facial lifting effect, less facial skin sagging and a reduction of crow’s feet wrinkles. Consumers may also perceive their skin to be lifted, smoother, more elastic and hydrated.


Conclusion The development of Peptovitae Matrix was inspired by the growing popularity of the dermocosmetic market. Consumers today are consistently on the watch for premium skincare ingredients which can deliver potent, visible efficacy to protect themselves from visible signs of skin ageing. Peptovitae Matrix demonstrated to act


in vitro on the pathways involved in oxidative stress and photoageing. The biomimetic peptide showed a positive impact on the proliferation of keratinocytes and fibroblasts, while protecting the cells against UV-induced accumulation of reactive oxygen species, cytotoxicity, and apoptosis. At the gene level, Peptovitae Matrix was also able to counteract UVA-induced down- regulation of genes encoding for ECM proteins (pro-collagen type 1, elastin, fibronectin) in fibroblasts along with a protective effect on UVB-induced down-regulation of sirtuin-1 and aquaporin-3 genes in keratinocytes. In vivo testing of Peptovitae Matrix at


2%, translated to improving signs of skin photoageing with a visual improvement of facial lifting (skin sagging) while contributing to the reduced appearance of crow’s feet wrinkles to help achieve the beauty aspirations of the consumers.


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PERSONAL CARE March 2023 smoothness Skin (**) Facial lifting


90% 80% 70% 60% 50%


(*) (°) (*)


Elasticity at the skin surface


Placebo ■ Peptovitae Matrix at 2% ■


(°) (**) Skin hydration Skin density


Statistics: Percentage on positive answer on Good or Very good efficacy on 20 volunteers Two- tailed binomial test (°) p<0.1 - Trend (*) p<0.05 (**) p<0.01


Figure 13: Self-assessment on several parameters which obtained ‘good and very good’ efficacy upon application of Peptovitae Matrix at 2% versus the placebo


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10. Huang AH, Chien AL. Photoaging: a Review of Current Literature. Current Dermatology Reports. 2020 Jan 20;9(1):22–9


PC


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Values of Circulating Insulin-Like Growth Factor-I Bioactivity in the Healthy Population: Comparison with Five Widely Used IGF-I Immunoassays. The Journal of Clinical Endocrinology & Metabolism. 2008 Jul 1;93(7):2539


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