78 HYGIENE


Novel cosmetic ingredient for oral hygiene


Laura Meunier, Dr. Florian Genrich, Dr. Steffen Nordzieke – Symrise


Due to the pandemic and the increased need for consumers to stay and feel clean, the personal hygiene sector has experienced a real upswing in 2020.1


While the interim focus was mainly


on hand hygiene, personal hygiene today has branched into a broad variety of applications ranging from scalp to toe including oral care. In this article, we present new results on a modern cosmetic ingredient for oral hygiene that answers the quest for safe environmentally friendly antimicrobial solutions. For decades, triclosan has been a preferred


ingredient in toothpaste and mouthwash thanks to its versatile hygiene benefits. In the last couple of years, the market has been gradually forced to move away from such conventional organohalogen technologies. This process has not only been accelerated by the US ban on triclosan from antibacterial soaps,2,3


the


global overuse of ingredients like triclosan and triclocarban and their environmental impact triggered more and more legal restrictions and consequently, cosmetic brands have phased these ingredients out of formulations to serve consumers with safer and more eco-friendly solutions. SymGuard® CD, [INCI: phenylpropanol, o-cymen-5-ol, decylene glycol] – hereafter described as the cosmetic hygiene ingredient - is one of the modern options for personal hygiene with key benefits in oral care.5,6


Antimicrobial activity relevant to oral hygiene Oral malodour is primarily caused by the enzymatic degradation of proteins and


SymGuard CD ■ Triclosan ■


100 80 60 40 20 0


amino acids. Typically formed malodourous components include volatile organosulfur (hydrogen sulfide, methyl mercaptan, dimethyl sulfide), indole, and skatole. The abundance of anaerobic gram-negative bacteria of the genera Porphyromonas and Fusobacterium is often correlated with stronger malodour.7,8 If we take a closer look at global consumer


expectations from oral hygiene products it becomes clear that multitasking antimicrobial solutions are a necessity for this product category. The top three benefits that global consumers expect from toothpaste are: fights cavities, freshens breath, and removes dental plaque. For mouthwash, the top five benefits expected by global consumers are: freshens breath, fights cavities, soothes sensitive gums, removes dental plaque,9


and is antibacterial.


activity against several microorganisms relevant to oral care.10


The cosmetic hygiene ingredient shows good This includes Streptococcus


0.06 0.125 0.25 0.5


Figure 1: Percentage of biofilm reduction by different concentrations of SymGuard CD versus triclosan


PERSONAL CARE March 2023


mutans, a leading organism in dental caries, and the two gram-negative species Porphyromonas gingivalis and Fusobacterium nucleatum which are linked to oral malodour or periodontal inflammation (Table 1).


Streptococcus mutans single species results (in vitro) In the oral cavity, S. mutans is the main bacterial


TABLE 1: MINIMUM INHIBITORY CONCENTRATIONS FOR SYMGUARD CD


Texture


Streptococcus mutans Porphyromonas gingivalis Fusobacterium nucleatum


MIC


500 ppm 2000 ppm 2000 ppm


genus responsible for tooth decay. This in vitro study evaluates the influence of the cosmetic hygiene ingredient on an S. mutans biofilm versus triclosan as a positive control. The biofilm was exposed to increasing concentrations of the blend (0.06%, 0.125%, 0.25%, 0.5%) or triclosan (dissolved in DMSO) for two minutes. For each value, five independent replicates were run to determine the minimal biofilm eradication concentration (MBEC). A low concentration of 0.06% cosmetic


hygiene ingredient already resulted in an approximately 20% reduction of biofilm activity, while higher concentrations of the cosmetic hygiene ingredient reduced the biofilm activity completely (Figure 1). For triclosan, all tested concentrations eradicated the biofilm by 100%. Out of these results, an MBEC of 0.125% was derived for the cosmetic hygiene ingredient and an MBEC of <0.06 % for triclosan.


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% Biofilm Reduction


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