80 HYGIENE A quantitative evaluation of relevant bacterial
strains was carried out through the collection of oral saliva on the first day of the test and after 28 days. As a result, the use of a mouthwash twice a day significantly reduced the impression of bad breath according to an expert’s rating (Figure 3). CH3
SH and CH3 SCH3 are known organosulfur
compounds associated with oral malodour. For the volunteers who used the mouthwash containing 0.3% cosmetic hygiene ingredient, a decrease in emitted organosulfur was detected, while for the placebo users, this decrease was not detected (Figure 4). For the volunteers who used the mouthwash
with 0.3% cosmetic hygiene ingredient, a stronger decrease of P. gingivalis and F. nucleatum was detected in parallel (Figure 5).
Preservative efficacy A preservative efficacy test has been conducted on an unpreserved flavoured mouthwash, comparing to the identical formula containing 0.3% cosmetic hygiene ingredient on top. The results with 0.3% cosmetic ingredient
show a clear preservation effect mainly on bacteria but also on C. albicans which will allow for a complete protection of oral care formulations while reducing the need for other preservatives (Figure 6).
Conclusion The liquid blend combination of phenylpropanol, o-cymen-5-ol, and decylene glycol is a modern cosmetic hygiene ingredient that provides significant antimicrobial efficacy for oral care products. The multifunctional, non-organohalogen
ingredient has an environmentally friendly profile which makes it a preferred ingredient in line with increasing legal and consumer requirements.11
It shows good performance
against oral microorganisms that are linked to the formation of dental plaques and oral malodour at a dosage of 0.3%.
PC
References 1. Vorster A. Regain consumer trust with modern hygiene technology. Pharmaceutical & Cosmetic Review (South Africa). 2020. Vol 47, No 5, 28
MOUTHWASH WITHOUT SYMGUARD CD
10.000.000 1.000.000 100.000 10.000 1.000 100 10
P.gingivalis
1600 1400 1200 1000 800 600 400 200 0
Mouthwash with 0.3% SymGuard CD ■ Placebo ■ F. nucleatum
D0 D28
900 800 700 600 500 400 300 200 100 0
*
D0
D28
Figure 5: Average amount of P. gingivalis and F. nucleatum in the volunteers’ mouths before and after 28 days of use of the mouthwash (*significant difference to baseline, p<0.05)
2. Halden RU. On the Need and Speed of Regulating Triclosan and Triclocarban in the United States. Environmental Science & Technology. 2014. 48 (7), 3603-3611
3. U.S. Food and Drug Administration (2016). FDA issues final rule on safety and effectiveness of antibacterial soaps.
https://www.fda.gov/ news-events/press-announcements/fda- issues-final-rule-safety-and-effectiveness- antibacterial-soaps
4. Scientific Committee on Consumer Safety. Opinion on triclocarban (SCCP/0851/04).
E.coli ■
P.aeruginosa ■
S.aureus ■
C.albicans ■
A.brasiliensis ■ MOUTHWASH WITH 0.3% SYMGUARD CD
0 2 7 Days 14 28
10.000.000 1.000.000 100.000 10.000 1.000 100 10
June 2005.
http://ec.europa.eu/health/ph_risk/ committees/04_sccp/docs/sccp_o_016.pdf
5. Pesaro M, Lange L, Schade V. Patent application WO2018036625A1; A Preservative Mixture. August 2016
6. Genrich F, Behnke S. A new era of personal hygiene - Consumer confidence without the environmental impact. Euro Cosmetics. 2021. 11/12 2021, 14-17
7. Allaker RP. Investigations into the micro-ecology of oral malodour in man and companion animals. J. Breath Res. 4 (2010) 017103 (6pp)
8. Takeshita T, Suzuki N, Nakano Y, Shimazaki Y, Yoneda M, Hirofuji T, Yamashita Y. Relationship between Oral Malodor and the Global Composition of Indigenous Bacterial Populations in Saliva. Appl. Environ. Microbiol. May 2010. Vol. 76 no. 9 2806-2814
9. Symrise. Oral Care Botanical Study – March 2020 / Among toothpaste users n=234 in the US; n=214 in DE, n=230 in FR, n=249 in BR, n=224 in IN
10. Hampelska K, Jaworska MM, Babalska ZŁ, Karpiński TM. The Role of Oral Microbiota in Intra-Oral Halitosis. J. Clin. Med. 2020. 9(8), 2484
0 2 7 Days Figure 6: Preservative efficacy test of two mouthwashes, one unpreserved and one with SymGuard CD PERSONAL CARE March 2023 14 28
11. Symrise expressly disclaims any implied warranty of fitness for a particular use. We recommend that prospective users determine for themselves the suitability of all materials. Symrise offers cosmetic ingredient solutions and recommends to always check for compliance with local regulations in place
www.personalcaremagazine.com
CFU/g
CFU/g
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