SCALP CARE 73
an alternative production strategy capable of generating complex recombinant proteins in a scalable and sustainable manner. In this approach, plants are engineered to
produce the desired protein directly within plant tissues. In the case of oleosome-fused proteins, the recombinant protein is expressed within developing oilseed cells where it becomes naturally incorporated into the oleosome structure. This method offers several advantages. First,
plant production systems eliminate the need for animal-derived cell cultures, reducing ethical and regulatory concerns associated with mammalian expression systems. Second, plant biofactories operate in
controlled greenhouse environments, allowing large-scale protein production with relatively low energy input and minimal environmental impact. Third, because the protein is produced already
fused to the oleosome structure, downstream processing requirements are simplified compared with conventional protein purification processes. The resulting ingredient is therefore both
biologically active and inherently stabilized through its association with the plant-derived oleosome particle.
Evaluation of the efficacy of cosmetic scalp treatments: randomized blind placebo- controlled study Materials and methods - study design A randomized single-blind clinical study was conducted to evaluate the efficacy of a cosmetic scalp treatment in improving hair density and scalp condition. Forty volunteers were enrolled in the study.
Twenty volunteers received the active formulation with 2% Oleosome-FGF2 (Serum A), while 20 volunteers received a placebo formulation (Serum B).
Figure 3: Before and after - Consumer from active treatment group
The treatment period lasted 84 days, during which participants applied the product twice daily directly to the scalp. Measurements were taken at baseline (T0), after 28 days (T28), after 56 days (T56), and after 84 days (T84). Volunteers were instructed not to use other scalp treatments during the study period.
Instrumentation Hair and scalp parameters were evaluated using validated dermo-cosmetic instrumentation: ■ C-CUBE Pixience digital phototrichogram system ■ Corneometer CM825 ■ Sebumeter SM815
Results Anagen/telogen ratio The active treatment significantly improved the
balance between anagen and telogen hair phases. Baseline anagen/telogen ratios were:
■ Serum A: 8.4 ■ Serum B: 8.3 Percentage changes for the active formulation were: ■ +14.0% after 28 days (statistically significant) ■ +15.4% after 56 days (statistically significant) ■ +17.0% after 84 days (statistically significant) In contrast, the placebo group showed smaller
changes, including +5.2% after 28 days and non- significant results at 56 and 84 days.
Hair density Hair density improved significantly in the active treatment group compared with placebo. Percentage changes for the active formulation
were: ■ +33.6% after 28 days (statistically significant) ■ +32.7% after 56 days (statistically significant)
T0 T84
www.personalcaremagazine.com
May 2026 PERSONAL CARE MAGAZINE
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