SKIN CARE 33
Collagen is protected against UV Daylight, maintaining its integrity.
With UV Daylight 0.8 BED
180% 160% 140% 120% 100% 80% 60% 40% 20% 0%
Non-exposed Placebo
Placebo
Without UV Daylight 0.8 BED Untreated
With UV Daylight 0.8 BED Placebo Blend 0.1%
-56% **
Blend 0.1%
The collagen hybridizing peptide linked to a fluorophore (red fluorescence) binds to damaged sites of the dermal tissue, where collagen fibres are broken: the redder the colour, the greater the damage.
Figure 8: Bar graph shows collagen protection from UV by the blend. Ex vivo skin was repetitively irradiated with UV daylight over three days. Images were analysed using Fiji software (fluorescence intensity and distribution). Placebo: 90% water and 10% DMSO
hours after SDS treatment, and four to six hours after the last daily application on day 1, 2, 3, 5 and 7. Figure 9 Study B shows the redness reduction
in a shave-induced irritation study. In this test, 20 subjects were enrolled,
17 subjects validated. T0 pre-shave: clinical evaluations of redness on the cheeks. T0 post- shave: evaluations were repeated five minutes after shaving. Gel containing 0.1% of the blend was applied
on half face. All evaluations were repeated at 5 and 30 min post-application. After evaluations, the placebo was applied on the untreated side. There was a significant reduction in redness as fast as five minutes and continuing to 30 minutes. Rapid soothing was also demonstrated in
a shave-induced irritation model using a 0.1% gel. Erythema was reduced by 46% within five minutes and by 59% at 30 minutes, with protection maintained over ten days (Figure 10). Such kinetics are highly relevant commercially. They support positioning not only in classical sensitive-skin care, but also in post-shave, post-stress, and compromised-skin applications where immediacy of benefit shapes consumer perception. A further dimension comes from instrumental
assessment of sensitivity itself. Using hyperspectral imaging and AI-assisted analysis, internal testing showed a significant downward trend in a skin sensitivity index, including a 7%
A
100 80 60 40 20 0
Day 0 after SDS Study B: Shave-induced irritation - in vivo B
3.5 3
2.5 2
1.5 1
0.5 0
D1 Post Shave D1 T5min post application D1 T30min post application
Figure 9: Study A. Bar graph depicts erythema reduction of the blend to baseline in as little as five days and faster than individual ingredients. Study B shows redness reduction in shave irritation
-46% * -59% ** Day 0 Study A: Synergistic Redness Relief - in vivo
Placebo ■ 0.1% Bisabolol ■ 0.001% Ginger Extract ■ 0.05% Blend ■
* * * * * * * * Day 2 Day 3 Day 5 * Day 7
* p<0.05 vs Placebo & synergistic * p<0.05 vs Placebo
Placebo ■ Blend ■
Back to initial state
www.personalcaremagazine.com
May 2026 PERSONAL CARE MAGAZINE
CHP content (Relative % to non-exposed untreated)
Variation Skin Redness (∆a* parameter)
Erythema, a-Value (%)
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