46 SENSITIVE SKIN D0, after aggression D4, placebo treatment
D4, treatment with 1% Ceratonia siliqua extract
No erythema
Considerable erythema
Figure 3: Effect of the Ceratonia siliqua extract at 1% on erythema after four days of application
the upper layers of the epidermis. This model is commonly used to assess the beneficial effects of wound healing treatments.9 The aim of this study was to determine the
capacity of the ingredient to improve the kinetics and quality of the repair of damaged skin. To this end, four parameters were studied, including skin barrier repair kinetics, post-lesion re- epithelialization, changes in erythema following the aggression and quality of healing (state of skin dryness and formation of scabs). The results demonstrated that the active
ingredient promotes recovery of the damaged skin barrier by acting as of the first applications. As a result of this rapid action, erythema (Figure 3), drying and scabs are attenuated. The Ceratonia siliqua extract is a natural
active ingredient 85% purified in galactomannans obtained from carob gum (Ceratonia siliqua). Studies have shown that the efficacy of the ingredient depends on the size, the structure and the origin of the galactomannans. The latter have a strong affinity for lectins described as having a beneficial effect on the healing process. In order to secure a sustainable supply of carob gum, Silab has created partnerships with several suppliers in the Mediterranean basin certified for organic agriculture and who provide carob gum whose quality is perfectly controlled. The Ceratonia siliqua extract is a perfectly
safe preservative-free powder that can be used without risks to adult consumers (including pregnant and breast-feeding women) and infants. Thanks to its positive action on the quality of healing, it is the recommended natural solution for wounded or damaged skin requiring repair.
PERSONAL CARE MAGAZINE May 2026
Conclusion Since its creation ten years ago, the strategy and dynamics of Silab Softcare rely on three principles of excellence: efficacy, safety and naturality. With a strong commitment to health, this
department develops specific in vitro and in vivo models to mimic the biological reality of the dermatological issue studied. These models are used to screen the most effective natural active molecules and to understand the pharmacological activity of the selected molecules in the context of the skin disorder under study. These data are complemented by clinical studies undertaken under medical supervision. As a result, the active ingredients developed by
Silab Softcare are specially designed to improve the condition of compromised skin, either for curative purposes or to accompany medical treatments or aesthetic procedures. With Ad-Resyl®
, Acnesium® and Cicactyl® ,
Silab Softcare offers safe and natural solutions to be used as part of dermo-cosmetic and dermatological care programs to treat atopic dermatitis, acne and wound healing.
compromised three-dimensional in vitro model mimicking atopic dermatitis. Br J Dermatol. 2015; Oct;173(4):1006-14
4. Verzeaux L, Vyumvuhore R, Boudier D, Le Guillou M, Bordes S, Essendoubi M, Manfait M, Closs B. Atopic skin: In vivo Raman identification of global molecular signature, a comparative study with healthy skin. Exp Dermatol. 2018; Apr;27(4):403-408
5. Mainzer C, Le Guillou M, Vyumvuhore R, Chadoutaud B, Bordes S, Closs B. Clinical Efficacy of Oligofructans from Ophiopogon japonicus in Reducing Atopic Dermatitis Flare- ups in Caucasian Patients. Acta Derm Venereol. 2019; Sep 1;99(10):858-864
6. Laclaverie M, Rouaud-Tinguely P, Grimaldi C, Jugé R, Marchand L, Aymard E, Closs B. Development and characterization of a 3D in vitro model mimicking acneic skin. Exp Dermatol. 2021; Mar;30(3):347-357
PCM
References 1. PubMed analysis: February 2019 2. Mehdipour Chari K, Enderami SE, Mansour RN, Hasanzadeh E, Amini Mahabadi J, Abazari M, Asadi P, Hojjat A. Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies. Regen Ther. 2024; Apr 6; 27: 251-258
3. Rouaud-Tinguely P, Boudier D, Marchand L, Barruche V, Bordes S, Coppin H, Roth MP, Closs B. From the morphological to the transcriptomic characterization of a
7. Attiogbe E, Larochelle S, Chaib Y, Mainzer C, Mauroux A, Bordes S, Closs B, Gilbert C, Moulin VJ. An in vitro autologous, vascularized, and immunocompetent Tissue Engineered Skin model obtained by the self-assembled approach. Acta Biomater. 2023; Sep 15;168:361- 371
8. Attiogbe E, Mareux E, Larochelle S, Mauroux A, Gofflo S, Mainzer C, Bordes S, Closs B, Gilbert C, Moulin VJ. An Autologous, Vascularized and Immunocompetent Tissue Engineered Skin to Highlight Inter-Individual Variability to Better Understand the Human Wound Healing. Wound Repair Regen. 2026; Jan-Feb;34(1):e70129
9. Wilhelm KP, Wilhelm D, Bielfeldt S. Models of wound healing: an emphasis on clinical studies. Skin Res Technol. 2017; Feb;23(1):3-12
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