24 LONGEVITY Control Stress (UV-A) 0.01% Bakuchiol NAD + BCR + Stress


0.005% Bakuchiol + Stress


1% Nicotinic Acid + Stress


0.005%: 1% (Bakuchiol: Nicotinic Acid) + Stress


Figure 6: Gene expression profile of bakuchiyl nicotinate


data using STRAT-M samples (mimicking full thickness skin) which showed the bakuchiol NAD+ ester is readily absorbed into skin and does not go systemic. This allows for just enough niacin to be


delivered for optimal NAD+ production but still thousands of times lower concentration than what would induce flushing.11,13


Combination treatments The tapestry of molecular pathways able to be leveraged with this unified approach is vast and


TABLE 1: Gene Name Aquaporin-3


Ceramide Synthase 2 Filaggrin


Collagen Type 4 Elastin


Matrix Metalloproteinase 1


Poly (ADP-Ribose) Family Member 1


Poly (ADP-Ribose) Family Member 2


Poly (ADP-Ribose) Family Member 9


Superoxide Dismutase 1


Tumour Necrosis Factor Alpha


vs. Bakuchiol (20ug/mL)


Not Tested Not Tested 2.1


6.6 2.2


-12.4 Not Tested Not Tested 8.7


Not Tested -17.6


PERSONAL CARE MAGAZINE May 2026


Bakuchiyl Nicotinate vs. Niacin (20ug/mL)


Fold up or Down Regulation Not Tested Not Tested 2.6 1.4


Non-Significant -10.4


Not Tested Not Tested 3.9


Not Tested -3.2


vs. Water (20ug/mL)


3.2 4.1


Not Tested Not Tested Not Tested


Not Tested 2.3 2.6


Not Tested 2.1


-2.8


Skin Longevity & Antioxidant defence


Functions


fine-tuneable. For example, in the longevity space, flavonoids like myricetin, quercetin, or apigenin are known for their ability to clear senescent cells and reduce the expression of CD38 (inflammatory receptor that consumes NAD+).14-16 Some of these compounds have also been


found to favourably shift the methylation profile of the epigenome. The combination of bakuchiyl nicotinate with these compounds can be highly synergistic as it also helps add an anti- senescence element, reinforces anti-inflammatory


activity, and synergistically boosts NAD+ further. Another powerful mode of action is to boost


cellular machinery (sirtuins) alongside their key resources ( NAD+ levels) through precursors. Plant stem cell technologies like BCR’s PEPTinGLOW CROP G use naturally derived peptides to boost sirtuins and neurocosmetic markers. Resveratrol has also been used to boost longevity markers in skin cells like sirtuins while also providing traditional benefits like brightening, collagen boosting, and more.17,18 In the ‘traditional’ space, retinoids can be


used for maximal retinoic acid receptor activation and differentiated activity. For example, retinoids increase exfoliation enzymes to a much greater extent than bakuchiol. The combination of retinoids with bakuchiyl


Hydration & Skin barrier repair


Extracellular Matrix Regulation


nicotinate can leverage a total solution of hydration, exfoliation, anti-inflammatory, antioxidant, and longevity. Skin firming can also be better achieved


through a hybrid approach by boosting collagen levels through peptides while leveraging longevity to reduce glycation, extracellular matrix breakdown, and reducing carbonylation or excess cross linking of collagen. The microbiome is another fruitful area for


hybrid approaches. Targeting dysbiosis, reducing inflammation, and priming the skin’s ability to respond to stress through NAD+/NADH or repair pathways allows for a much more holistic solution than traditional methods alone.


Conclusion With every new cycle of innovation, Nataraja’s dance of destructive creation perpetuates, and the paradigm ultimately shifts. It does not mean abandonment of the past as the past is a necessary constituent of the future.


www.personalcaremagazine.com


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