SENSITIVE SKIN 43
Strategies for treating compromised skin
Mélanie Coirier, Elodie Aymard, Hélène Muchico, Brigitte Closs – Silab ABSTRACT
Environmental stresses, age, lifestyle or medicated treatments may compromise the skin and cause the appearance of skin disorders - atopic dermatitis, psoriasis, rosacea, acne - making the skin more sensitive and reactive. In order to provide solutions for compromised skin, Silab launched Silab Softcare department in 2016. By relying on the expertise, innovative capacity and efficiency of the Silab organization, this dedicated department provides solutions specially designed to be used as part of dermo- cosmetic and dermatological care programs. On the occasion of its tenth anniversary, Silab Softcare reinforces its unique approach to research by displaying a novelty, thus increasing its range of effective, safe and natural solutions to three products. The latter have been specifically designed to reactivate the biological mechanisms of cutaneous repair inherent in the proper functioning of healthy skin
Ten years ago, Silab launched Silab Softcare, an in-house department fully dedicated to the care of compromised skin. It develops, manufactures and markets patented active ingredients specifically designed to be used as part of dermo- cosmetic and dermatological care programs. The original positioning of the products
developed by Silab Softcare revolves around strategic focuses, among which: developing original in vitro and in vivo models mimicking the biological process of the pathology, providing proofs of efficacy and proposing natural active molecules, in the form of preservative-free powders. Since its creation, Silab Softcare has dedicated
its research to two chronic dermatological pathologies which today affect a large part of the population: atopic dermatitis and acne. Indeed, epidemiological studies classify atopic dermatitis as a public health problem,1
and acne
as the most widespread skin disorder. Recently, Silab enlarged its research to wound healing, a universal issue of fundamental importance in the field of medical care. Globally, about 300 million patients in fact are afflicted with chronic skin lesions and 100 million patients have traumatic cutaneous wounds.2 This publication aims to highlight the research work conducted by Silab Softcare on these three
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dermatological issues and to identify effective, natural and safe solutions to treat them.
Atopic dermatitis Original in vitro and in vivo models to investigate atopic skin From a molecular standpoint, the major alterations leading to the appearance of atopic dermatitis are an altered barrier function, an exacerbated inflammatory response, a modification of the cutaneous microbiota and neuronal hyperreactivity. To study this pathology, different in vitro and
in vivo models were developed in-house.3-4 First, a model compromised with altered
barrier function was designed. It corresponds to a normal reconstructed epidermis exposed to an inflammatory cocktail prepared with mediators and cytokines characteristic of the disease. It was subjected to additional stress by a solution of sodium lauryl sulfate (SLS) that alters the barrier function. The second model developed was a model
compromised with altered barrier function and colonized by Staphylococcus aureus. This normal reconstructed epidermis was exposed to the same inflammatory cocktail, subjected to additional stress by a solution of sodium lauryl sulfate (SLS) and exposed to aggression by a bacterial
species characteristic of atopic dermatitis (Staphylococcus aureus). In addition, Raman microspectroscopy
was used in vivo to determine the molecular signature of adult volunteers with this pathology in comparison to healthy volunteers. The Raman microspectroscopy studies were carried out by the groups of Professor Arlette Baillet-Guffroy (Analytical Chemistry group, EA4041, University Paris-Sud 11) and Professor Michel Manfait (MeDIAN-CNRS UMR 7369, Reims Champagne- Ardenne School of Pharmacy). This molecular signature directly showed
changes in the lipid component in vivo (organization and conformation) and in the aqueous component (total water, bound water). With atopic dermatitis, there are changes in
the conformation and organization of lipids that reduce the compactness of lipid structures, and the parameters of total water and bound water are significantly reduced. These deteriorations explain the loss of the skin’s barrier properties and also its dryness that is a feature of this pathology.
Development of a natural solution dedicated to atopic skin Thanks to these in vitro and in vivo models, Silab
May 2026 PERSONAL CARE MAGAZINE
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