DISINFECTANTS
Conclusion The virucidal activity of Jungbunzlauer L(+)-lactic acid against enveloped viruses was successfully demonstrated using the EN14476 test. First proof-of-principle results demonstrate its efficacy in aqueous solutions with a concentration of 0.9% and a contact time of one minute or a concentration of 0.45% and a contact time of five minutes. Neither concentration requires hazardous labelling, though the low pH value of these formulations means they are suitable for surface disinfection only. With regards to skin disinfection, the efficacy
of a greener skin disinfection gel containing the two active ingredients lactic acid and ethanol (pH 3.5, contact time 30 seconds) was demonstrated. It was further shown that incorporating xanthan gum into formulations of this type simplifies application without impairing the disinfectant action. Additionally, the presence of lactate has a proven positive effect on skin hydration due to its high water-holding capacity. L(+)-lactic acid has virucidal activity against
CK 2ChAd 20.qxp_Layout 1 14/09/2021 14:57 Page 1
all enveloped viruses, including coronaviruses. As a fermentation-derived product, it meets market and consumer demands for green, gentle yet effective solutions. Jungbunzlauer lactic acid, sodium lactate, potassium lactate and xanthan gum are also Ecocert- and COSMOS-approved raw materials for use in natural personal care products and detergents, while lactic acid is also approved under the BPR for the relevant PTs 1 and 2. It is a valuable green biocide with power against both enveloped viruses and bacteria.
TABLE 3: FORMULATION A FOR THE FULL EN14476 TESTS. Ingredient
INCI Water Ethanol1
L(+)-Lactic Acid 88% Heat Stable. Biocidal Grade2 Xanthan Gum FNCSP2
Potassium L(+)-Lactate 60%, Personal Care Grade2
Note: pH of the formulation set to 3.5 with potassium lactate Suppliers: 1. Diverse 2. Jungbunzlauer
TABLE 4: RESULTS OF DIFFERENT CONCENTRATIONS OF FORMULATION A IN A FULL EN14476 AGAINST VACCINIA VIRUS (MVA, DIRTY CONDITIONS, 20°C)
Formulation
10% of formulation A 80% of formulation A
References 1. Poli G, Biondi PA, Uberti F, Ponti W, Balsari A, Cantoni A. Food Chem. 1979. 4, 251–258
2. McDonnell G, Russell AD. Clin. Microbiol. Rev. 1999. 12, 147–179
3. Jokura Y, Ishikawa S, Tokuda H, Imokawa G. J. Invest. Dermatol. 1995, 104, 806–812
4. Nakagawa N, Sakai S, Matsumoto M, Yamada M, Nagano M, Yuki T, Sumida Y, Uchiwa H. J. Invest. Dermatol. 2004. 122, 755–763
5. Neubauer MP, von Nessen K, Weiher F. Jungbunzlauer Fact Sheet 2017
PC
6. Weiher F, Neubauer MP. H&PC Today. 2017. 12, 20–21
Contact time 30s FAIL PASS
7. ECHA. Guidance on the Biocidal Products Regulation: Volume II Efficacy – Assessment and Evaluation (Parts B and C). Version 3.0, 2018
8. EN 14476 2019. Chemical disinfectants & antiseptics – Quantitative suspension test for the evaluation of virucidal activity in the medical area – Test method & requirements (Phase 2/Step 1)
9. Rotter ML, Koller W, Neumann W. J. Hosp. Infect. 1991. 18, 57–63
10. Ahmed-Lecheheb D, Cunat L, Hartemann P, Hautemanir A. Am. J. Infect. Control. 2012. 40, 160–164
Aqua Ethanol Lactic Acid Xanthan Gum Potassium Lactate
93
% w/w qs 44
1.70
0.56 qs
www.personalcaremagazine.com
November 2021 PERSONAL CARE
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104
