88 SKIN CARE
Day
Post-application repair
TEWL & erythema Assessment
Figure 11: Repair action - clinical protocol
chemical stress with SLS significantly reduced the extent of skin barrier damage. This supports the therapeutic action of the lipophilic active in promoting skin barrier function, even after a single application. The lipophilic active significantly
accelerates the barrier function recovery when applied after stress (a reduction in TEWL of -15.1%, -28.6%, -32.2% and -37.4% after 30 minutes, one hour, two hours and 24 hours from patch removal, respectively). The placebo did not show any difference compared to untreated skin (Figure 12). The measurement of skin erythema also
demonstrated the therapeutic effectiveness of the lipophilic active formulation. Untreated skin still showed clinical signs of skin irritation after 24 hours from SLS exposure. Post-SLS exposure application of the lipophilic active formulation hastened the recovery of skin homeostasis (a reduction in erythema -6.6%, -6.4%, - 8.4% and -10.1% after 30 minutes, one hour, two hours and 24 hours from patch removal, respectively) more than the application of the placebo (Figure 13). The lipophilic active helps to repair the skin from chemically induced erythema, showing a soothing effect after a single application.
Conclusion Public awareness of the importance of hand sanitisation during the current pandemic event
Product applied after SLS exposure -Post-treatment -One single application
0 -5
-10 -15
-20 -25 -30 -35 -40
is likely to have a far-reaching effect on hygiene habits across the globe. New norms of hygiene, such as the routine use of hand sanitisers and frequent handwashing, will continue beyond the COVID-19 era. It is essential to find solutions for cleaning and sanitising the skin while maintaining its main function as a barrier to external agents, including pathogens. Chemical agents contained in hand
sanitisers and personal cleansing products can affect the top layers of the stratum corneum, disrupting the lipid matrix of the skin barrier and causing excessive TEWL. They can also penetrate deeper into the skin, interacting with living cells and initiating an inflammatory reaction, ultimately leading to skin erythema. The lipophilic active has shown a way to
counteract these negative effects, thanks to the synergistic effect of its main components, Echium plantagineum seed oil, Cninidium monnieri fruit extract and Rosmarinus officinalis leaf extract. This combination plays a key role in the restoration of the skin lipid matrix and in anti-inflammatory processes, preventing and repairing skin barrier damages, improving skin hydration levels and decreasing irritation and skin sensitivity (Figure 14). In a ‘new normal’ skincare scenario, where non-irritating products are in high demand, the lipophilic active can offer several functional solutions. It can be added directly to hygiene products, such as alcohol-based hand sanitisers and personal cleansing products, or it can be used in moisturising treatments with both protective and therapeutic functions against chemical stress.
Untreated skin ■ Lipophilic active ■ Placebo ■
Product applied after SLS exposure -Post-treatment -One single application
6 4 2 0
-2 -4 -6 -8
30’ 1h 2h 24h 30’ 1h 2h 24h 30’ Time after SLS-patch removal Figure 12: Variation in TEWL in the repairing protocol. PERSONAL CARE November 2021 1h 2h 24h
-10 -12
30’ 1h 2h 24h 30’ 1h 2h 24h 30’ Time after SLS-patch removal Figure 13: Variation in skin erythema in the repairing protocol
www.personalcaremagazine.com 1h 2h 24h The use of an alcohol-based hand sanitiser
containing 1% lipophilic active was successful in preventing the damage caused by ethanol. An improvement in the skin barrier function was observed after its first application, accompanied by an immediate increase in skin moisturisation, which persisted through time. The clinical action of the lipophilic active also
extends to its ability to reduce the aggressiveness of surfactant agents. It acts as a protective ‘mask’, if applied before stress, preventing damage to the barrier function and skin sensitivity, and also as a ‘destroyer’ of chemical agents, if applied after the stress, accelerating skin barrier repair and reducing skin irritation.
References 1. Beiu C, Mihai M, Popa L, Cima L, Popescu M.N. Frequent hand washing for COVID-19 prevention can cause hand dermatitis: Management tips. Cureus. 2020;12(4):e7506. doi: 10.7759/cureus.7506
2. Berardi A, Perinelli D.R, Merchant H.A, Bisharat L, Basheti I.A, Bonacucina G, Cespi M, Palmieri GF. Hand sanitisers amid COVID-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand. Int. J. Pharm. 2020;584:119431. doi: 10.1016/j. ijpharm.2020.119431
3. Golin AP, Choi D, Ghahary A. Hand sanitisers: A review of ingredients, mechanisms of action, modes of delivery, and efficacy against coronaviruses. Am. J. Infect. Control.
Untreated skin ■ Lipophilic active ■ Placebo ■ Baseline
0 1
10
11
2% SLS Product application -One single application 12
-After chemical stress 13
30’ 1h 2h 24h Effect of post-treatment
PC
% variation in TEWL repairing effect
% variation in TEWL repairing effect
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