ANTI-POLLUTION
is common for individuals to be exposed to all three of these threats at the same time, every time they go outside and if they do not effectively cover their heads, the scalp can be exposed even if the individuals have thick hair. Topical application of the formulations
containing between 1 and 3% of the antioxidant complex can help to minimise the formation of cellular ROS in the DP cells, based on the in vitro results demonstrated in these studies. This may be particularly important as it is not common for individuals to cover or treat their scalps with sunscreens, which could potentially help reduce the impacts from UVB radiation. However, even sunscreens may have limited impact from the effects of urban particulate pollution or HEV light that are also common exogenous threats in both urban and rural locales.
References 1. Lemasters JJ, Ramshesh VK, Lovelace GL, Lim J, Wright GD, Harland D, Dawson TL. Compartmentation of mitochondrial and oxidative metabolism in growing hair follicles: A ring of fire. J. Invest. Dermatol. 2017: 137:1434-1444
Siltech 2ChAd 20.qxp_Layout 1 09/09/2021 11:35 Page 1
2. Calvo-Sanchez MI, Fernandez-Martos S, Espada J. A photodynamic tool to promote a sustained ROS-dependent growth of human hair follicle in ex vivo culture. Method. Mol. Biol. 2021: 2202:51-61
3. Calvo-SanchezMI, Fernandez-Martos S, Montoya MI, Espada J. Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient
30 minute exposure (13.5J/cm2)■ 60 minute exposure (27J/cm2 PC
45.00 40.00 35.00 30.00 25.00 20.00 15.00 10.00 5.00 0.00
)■
67
* * * * * Non-Exposed Untreated
0.015% Trolox 0.005% BHT 0.001% BHT 3% SC-Help Defense
Treatment
Figure 4: ROS formation due to exposure of DP cells to 13.5 mJ/cm2 27 mJ/cm2
of blue light for 60 minutes Note: Measured in RFUs. Asterisks indicate statistical significance against untreated DP cells
endogenous production of ROS. Sci. Rep. 2019: 9: 4509. doi: 10.1038/s41598-019- 39992-8.
4. Grabenhofer R. Beiersdorf refutes reports that artificial blue light causes skin damage. Cosmet. Toilet. Online. 2021
5. Duteil L, Queille-Roussel C, Lacour JP, Montaudie H, Passeron T. Short-term
exposure to blue light emitted by electronic devices does not worsen melasma. J. Am. Acad. Dermatol. 2020: 83:913-914.
6. Jia W, Diwakar G, Kata N, Kern D, Milner T. Quantification of blue light irradiation dose emitted by electronic devices and its potential impact on human skin. J. Invest. Dermatol. 2021: 141:S90.6.
of blue light for 30 minutes &
1% SC-Help Defense
* * * *
www.personalcaremagazine.com
November 2021 PERSONAL CARE
ROS Formulation (RFU)
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