SKIN CARE


Activoil Echnidium ZRO for skin barrier function


Dr Valeria Quaranta - Innovacos Corp., US


Today the importance of accurate personal hygiene is globally recognised in preventing the spread of the COVID-19 virus. However, attention must also be paid to the possible negative consequences for the skin. The regular use of alcohol-based gels or


cleansing products is usually well-tolerated, but repeated exposure to water and other chemical agents can induce several pathophysiologic changes, such as epidermal barrier disruption, keratinocyte impairment, the subsequent release of proinflammatory cytokines, the activation of the skin’s immune system and delayed-type hypersensitivity reactions. Adverse dermatologic effects, such as excessive skin dryness, skin irritation or even contact dermatitis, can occur, especially in individuals with a history of atopic dermatitis (Figure 1).1 Alcohol-based sanitisers have a key role


in mitigating the transmission of pathogens in healthcare settings. The US Center for Disease Control & Prevention (CDC) recommends using one that contains at least 60% alcohol as a reasonable alternative to handwashing, if the hands are not visibly dirty and greasy.2 Alcohol-based sanitisers work by killing germs and viruses. Their viral targets are predominantly the viral lipid envelope and the protein capsid, which contains and protects the genetic material, and the genetic material itself.3 However, lipid extraction and the


denaturation of proteins, due to alcohol topical application, may be relevant also for the skin, in particular for the intercellular lipid


TEWL


Skin dryness Skin barrier


lipid disruption Erythema Inflammation


Enhanced efficacy Stability against oxidation Compatibility with formulation


Figure 2: Activoil Echnidium ZRO: a natural defence for the skin


structure and stratum corneum enzymes that are involved in barrier functions, causing skin dryness.4


acts as a skin-penetration enhancer and may facilitate the transdermal absorption of irritating agents, increasing skin sensitivity.5 Personal cleansing products may rinse


away germs and dirt, but, at the same time, they also strip away the skin’s natural protective lipids, causing it to dry out. Surfactants, the main ingredients of cleansing products, are known to induce skin irritation by damaging the barrier proprieties of the


Chemical stress ♦Surfactants ♦Pollutants ♦Sanitiser agents ♦Prolonged exposure to water


-α-linolenic acid -Stearidonic acid


)


-Osthol ●


In addition, topically applied ethanol


stratum corneum, the outer layer of the skin, and denaturing proteins in the epidermis and dermis.6


The skin is the outermost layer of the


body and is the first line of defence against a multitude of external pathogens and environmental attacks.7


Unfortunately, a


compromised skin barrier is also a source of pathogen access. For this reason, restoring the skin barrier function is just as important as disinfecting the skin. As part of the Activoil™ series, Innovacos


has developed Activoil Echnidium ZRO (INCI: Echium Plantagineum Seed Oil, Octyldodecanol, Octyldodecyl Oleate, Octyldodecyl Stearoyl Stearate, Cnidium Monnieri Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract; hereafter referred to as ‘the lipophilic active’). This represents a natural defence for the


skin from the aggressiveness of both alcohol- based sanitisers and strong cleansing products (Figure 2). It combines the best of Echium seed oil with Cnidium monnieri fruit supercritical CO2


extract, in a lipophilic matrix, stabilised


from oxidation with Rosemary extract (Figure 3). Echium oil is obtained from Echium


plantagineum seeds and is a powerful source of omega-3 and -6 essential fatty acids, such as α- and γ-linolenic acid (ALA, 18:3 n-3, GLA, 18:3 n-6) and stearidonic acid (SDA, 18:4 n-3). Essential fatty acids have a key role in epidermal homeostasis - their deficiency results in a characteristic scaly skin disorder and excessive trans-epidermal water loss (TEWL).8


● Echium Plantagineum seed oil omega-3FA


● Cnidium monnieri fruit extract -SCFE (CO2


Rosemary leaf extract -Antioxidant protection


85


Figure 1: Cutaneous effects of chemical stress www.personalcaremagazine.com


Figure 3: Composition of Activoil Echnidium ZRO November 2021 PERSONAL CARE

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