SKIN MICROBIOME


Amino acid derivative for skin microbiome balance


Shiqi Wang, Masato Yoshioka - Seiwa Kasei


In recent years, scientific research has shed light on a fascinating aspect of our skin’s ecosystem: the microbiome. The skin microbiome, a complex community of microorganisms residing on the skin’s surface, has proven to play a pivotal role in maintaining skin health.1,2


There are more than


1,000 species of microorganism on the skin, and the composition of the skin microbiome depends on individuals and it changes daily. Imbalances and reductions in the diversity of the skin’s resident microorganisms can lead to skin problems.


This article aims to highlight the significance


of a balanced microbiome for vibrant and youthful skin, and elucidates the role of a novel amino acid derivative, Aminoflora, in addressing the issues of microbiome balance and long- lasting moisturisation.


The skin microbiome The skin is the largest organ of the body, acts as a physical barrier between the body and the outside, and the outermost part of the body that can come into direct contact with the environment.3,4 Our skin is home to trillions of


microorganisms, like bacteria, fungi, and viruses. These invisible life-forms are known as the skin microbiome. In circumstances where the barrier is broken or when the balance of the skin microbiome is disturbed, skin disease or even systemic disease can result.5 The representative microorganisms that


constitute the skin microbiome include Staphylococcus epidermidis (good microorganisms), Staphylococcus aureus (bad microorganisms), and Cutibacterium acnes (opportunistic microorganisms). Good microorganisms positively affect the microbiome balance, while bad microorganisms affect the microbiome balance and cause skin problems.


63


The opportunistic microorganism, acts as a


good microorganism to keep the skin healthy, and the diversity of microorganisms inhabiting the skin is abundant. However, when the skin is rough, the opportunistic microorganism becomes the bad microorganisms, and the balance of the skin microbiome in a healthy state is disrupted. Therefore, it is vital to maintain a balanced skin microbiome in order to get a healthy skin condition.


Aminoflora Aminoflora (INCI: Dihydroxypropyl Arginine HCl) is a 30% aqueous solution of the active ingredient. Aminoflora was developed by combining two molecules, glycerin and arginine,


CH2 CH OH OH Figure 1: Structure of Aminoflora www.personalcaremagazine.com CH2 NH


COOH CH


(CH2 )3 NH C


through our unique technology.6 Glycerin is known as a general purpose moisturiser in cosmetics,7


while arginine is an


amino acid that is also included in the natural moisturising factor (NMF) ingredient that plays a role in the skin’s barrier function. Aminoflora is a cosmetic ingredient and has a unique structure in which a dihydroxypropyl group is combined to the amino group of arginine (Figure 1). In addition to its excellent moisturising effect


derived from glycerin, Aminoflora has enhanced adsorption to skin and hair surface, due to the cationic nature of arginine. We have continued to conduct in-depth


research in response to market development trends and have found that Aminoflora has excellent effects on balancing the skin microbiome. Unlike traditional moisturisers, Aminoflora does not have a negative impact on the skin microbiome even when left on the skin surface for a long time.


NH2 NH2


CI


The role of Aminoflora in balancing skin microbiome We will use utilization experiments to confirm the effect of Aminoflora in balancing skin microbiome.


Utilization ‘Utilization’ is a biological phenomenon that a given substance is used as a nutrient by


June 2024 PERSONAL CARE


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80