SKIN CARE
Novel active illuminating the path to radiant skin
Mariana Yamamoto – Chemyunion
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The face and hands serve as the canvas of our age, revealing the first brushstrokes of the passage of time. The emergence of telltale signs such as wrinkles, sagging, dryness, age spots, freckles, and discoloration signifies the intricate dance between ageing and skin health. This article delves into the fascinating world
of age spots, with a particular focus on their formation, exploring the interplay between melanin, lipofuscin, and the essential cellular processes of autophagy and proteasome activity.
Age spot formation Age spots manifest as light brown to black pigmented lesions, varying in size from millimetres to small centimetres. Typically appearing on sun-exposed skin, these spots are not solely a result of melanin accumulation but also involve the presence of ‘cellular waste’ or lipofuscin.1,2 Lipofuscin is a yellow-brown pigment that
accumulates in cells as they age. It is formed by residues of cellular material that are not fully digested or eliminated through the normal cellular renewal process. In simple terms, lipofuscin is commonly referred to as the ‘ageing pigment’ and is associated with the buildup of cellular waste over time.3
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Autophagy and proteasome activity: the natural cellular renewal pathway Understanding the intricate mechanisms of autophagy is crucial in the pursuit of innovative skincare solutions. This cellular self-cleaning process is induced during nutrient deprivation, orchestrated by the dissociation of the mTORC1 protein complex. This crucial step triggers partial dephosphorylation, initiating the autophagic mechanism. Notably, mTOR, a key component in autophagy regulation, ensures homeostasis, responding to the cell’s physiological conditions and environmental stress. Reducing mTOR levels is essential for autophagy induction playing pivotal roles in phagophore and autophagosome biogenesis.4 The widely used marker LC3 identifies
autophagosome formation, while various autophagy-related proteins (ATGs) contribute to membrane formation. The Parkin protein stands out for monitoring and selecting damaged mitochondria, facilitating their autophagic degradation.4 While autophagy is crucial, its sole action is
not sufficient to prevent lipofuscin formation. The proteasome system complements autophagy, but lipofuscin accumulation inhibits proteasome activity. Mitigating cellular waste requires the
synergy of autophagy and proteasome systems, with autophagy proving more efficient in removing oxidized proteins in aged cells.5 Although distinct processes, enhancing
autophagy and proteasome activity synergistically increases the capacity to recycle damaged biological material in the cytosol. This proves to be an effective strategy in reducing signs of skin ageing, ensuring compensatory and effective communication between these vital mechanisms.6 In the pursuit of combating age
spots, Chemyunion introduces Iselight, a groundbreaking active ingredient born from meticulous research and ingredient screening. This new solution targets the core factors contributing to age spot formation by enhancing the homeostasis of the cellular detoxification system. Iselight operates through the activation of
autophagy and proteasome activity, effectively reducing different types of skin blemishes. The synergy between the resurrection plant and green coffee extracts forms the basis of Iselight, blending the antioxidant power of green coffee with the regenerative vitality of the resurrection plant.
The fusion of science and nature for radiant and healthy skin Myrothamnus flabellifolia, recognized as the
June 2024 PERSONAL CARE
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