SKIN CARE A Placebo ■ 2% Zenerity biotech ingredient ■ 0 -1 -2 -3 -2.7% C -4 0 days 28 days D -4 0 days -3.7% 28 days 0 -1 -2 -3 B Placebo ■ 2% Zenerity biotech ingredient ■
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Female volunteer 70, 55 years old
Female volunteer 20, 57 years old
Figure 11: Variation (%) of the wrinkle length in A) the crow´s feet area (*p<0.05 vs. initial time), and B) the forehead (****p<0.0001 vs. initial time; low significant 0.05<p<0.1 vs. placebo). C, D) Representative images showing the anti-wrinkle effect
with a powerful solution that addresses the underlying causes of sensitive skin, while promoting overall skin health and combating the ageing process.
PC
References 1. Liakou AI et al. Nutritional clinical studies in dermatology. J. Drugs Dermatol. 2013
2. Sawada Y, Saito-Sasaki N, Mashima E, Nakamura M. Daily Lifestyle and Inflammatory Skin Diseases. Int. J. Mol. Sci. 2021; May 14;22(10):5204
3. Cao C, Xiao Z, Wu Y, Ge C. Diet and Skin Aging-From the Perspective of Food Nutrition. Nutrients. 2020; Mar 24;12(3):870
4. Rider P, Voronov E, Dinarello CA, Apte RN, Cohen I. Alarmins: feel the stress. J. Immunol. 2017; Feb 15;198(4):1395-1402
A 0
-2 -4 -6 -8
-10 -12 -14
0 days 28 days
5. Gkogkolou P, Böhm P. Advanced glycation end products: key players in skin aging? Dermatoendocrinol. 2012; Jul 1;4(3):259- 70
6. Lee SA et al. The role of high mobility group box 1 in innate immunity. Yonsei Med J. 2014
7. Sorci G, Riuzzi F, Giambanco I, Donato R. RAGE in tissue homeostasis, repair and regeneration. Biochim. Biophys. Acta. 2013; Jan;1833(1):101-9
8. Franceschi C, Garagnani P, Vitale G, Capri M, Salvioli S. Inflammaging and ‘Garb- aging’. Trends Endocrinol. Metab. 2017; Mar;28(3):199-212
9. Terman A. Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox Report. 2001; 6(1):15-26 10. Michelitsch JW, Michelitsch TM.
Placebo ■ 2% Zenerity biotech ingredient ■ B
Development of age spots as a result of accumulation of aged cells in aged skin. 2015
11. Skoczynska A, Budzisz E, Trznadel- Grodzka E, Rotsztejn H. Melanin and lipofuscin as hallmarks of skin aging. Postepy. Dermatol. Alergol. 2017; Apr;34(2):97-103
12. Mourelle ML, Gómez CP, Legido JL. Hydrobiome of Thermal Waters: Potential Use in Dermocosmetics. Cosmetics. 2023; 10(4):94
13. Nicoletti G, Saler M, Pellegatta T, Tresoldi MM, Bonfanti V, Malovini A, Faga A, Riva F. Ex vivo regenerative effects of a spring water. Biomed. Rep. 2017; Dec;7(6):508- 514.
14. Baumann LS. Cosmetic dermatology: principles and practice. McGraw Hill
-11.1%
Female volunteer 41, 52 years old
Figure 12: A) Variation (%) in the number of dark spots (***p<0.001 vs. initial time; low significance 0.05<p<0.1 vs. placebo). B) Representative images showing a reduction in the number of dark spots
www.personalcaremagazine.com June 2024 PERSONAL CARE
Dark spots number mean variation (%)
Crow's feet wrinkle length mean variation (%)
Forehead wrinkle length mean variation (%)
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