SKIN MICROBIOME


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cause such disorders, the microbiome is a field personal care innovators want to play in. What does this mean for the future market


of skin care? What will consumers see on the product shelves as a response to this new research? It is apparent that skin care is intricately intertwined with the fascinating world of the microbiome, a complex ecosystem of microorganisms that inhabit our skin. As this scientific understanding of the


microbiome deepens, skin care practices are sure to revolutionize, and will introduce a new era of microbiome-centric treatments tailored to individual needs. Promising areas of study could involve identifying the microbiome profile associated with healthy skin and then one with common skin concerns and comparing the difference. Researchers are currently working on


identifying patterns or biomarkers to enhance microbiome-targeted therapies designed to restore microbial balance. Therefore, perhaps products with specifically tailored microbiome benefits will become more common, from probiotic or prebiotic skin care to microbiome- modulation products. In addition to topical treatments and


For time kill test results, values TKR1 and TKR2 at times t1 and t2, the AUC between those two time points is equivalent to the product of difference in time and the average of the two time kill result values. The data shown below in Table 2 and Figure


1 displays time kill results using an antimicrobial- free yeast-derived extract. From this particular run, the data obtained met the criteria for a valid assay as the control performed as anticipated across all microorganisms. Dendritic cells incubated with the antimicrobial-free yeast-derived active at 0.01%, 0.1%, and 1.0% prevented growth in detrimental microorganisms tested within 30 seconds and maintained commensal microbiota. As shown in Table 2 and Figure 1, the signaling


molecules from untreated dendritic cells were unable to kill 100% of all microorganisms tested at any time interval. Cumulatively, the media from untreated dendritic cells killed 98%, 90%, and 60% of the microorganisms for S.aureus, P.aeruginosa, and S.epidermidis, respectively. By comparing the percentages of microorganisms killed, these data demonstrate the signaling molecules from untreated dendritic cells allowed for growth of both the detrimental and commensal microorganisms tested. Conversely, the signaling molecules from


dendritic cells treated with any concentration of the antimicrobial-free yeast-derived active prevented all growth of the detrimental microorganisms, S.aureus and P.aeruginosa, at every time point. The media from dendritic cells treated with 0.01%, 0.1%, and 1% antimicrobial- free yeast-derived active only killed 69%, 77%, and 58% of the commensal microbiota, S.epidermidis, respectively. By comparing the percentages of detrimental


and commensal microorganisms killed, the data demonstrate paracrine signaling molecules from


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dendritic cells exposed to the antimicrobial- free yeast-derived active prevented growth of detrimental microorganisms while maintaining commensal microbiota commonly found on the skin.


The foundations and results of this assay are


significant, as it represents a groundbreaking advancement in the burgeoning field of immunocosmetics. By deciphering the intricate workings of the skin microbiome, it offers a pivotal tool for understanding how to effectively modulate and influence skin health. This breakthrough allows researchers and skin care innovators to unlock the secrets of the skin microbiome, paving the way for targeted interventions and personalized cosmetic solutions that harness the power of microbiome manipulation for optimal skin wellness.


Barely scratching the surface of possibilities As previously mentioned, the code has not necessarily been cracked when it comes to the skin microbiome just yet. Research has only scratched the surface, and it is a race to see which brands will pioneer in this innovative technology. Besides claiming ‘microbiome-friendly’, brands have not effectively communicated in the skin’s microbiome through their marketing. However, the interest from consumers is


obvious, and the immuno-cosmetic market will only continue to grow. In 2022, the market size for global microbiome skin care products was valued at $381.5m and is expected to grow at a compound annual growth rate of 10.9% from 2023 to 2030.9 Contributing to this exponential growth is


that multiple consumers are affected daily by skin conditions that can disrupt the microbiome, such as acne, psoriasis, and eczema. Now that research is coming out that caring for the skin’s microbiome plays a crucial role in regulating immune responses, reducing inflammation, and protecting our skin from pathogens that


building off the previously mentioned research on the skin-gut axis and how that plays a critical role in skin health, consumers might also see a rise in ingestible skin care products, like probiotics and dietary supplements aimed at promoting gut health and indirectly benefiting the skin. Overall, the future of skin care is filled


with endless possibilities as the secrets of the microbiome continue to be unlocked. With continued research and innovation, consumers can look forward to a new era of skin care that harnesses the power of the microbiome to achieve healthy, radiant skin from the inside out.


PC


References 1. Astin JA. Why patients use alternative medicine: results of a national study. JAMA. 1998; May 20;279(19):1548-53


2. Cresci GA, Bawden E. Gut Microbiome: What We Do and Don’t Know. Nutr. Clin. Pract. 2015; Dec;30(6):734-46


3. Salem I et al. The gut microbiome as a major regulator of the gut-skin axis. Frontiers in Microbiology. 2018; 9: 382698


4. Pilkington SM, Bulfone-Paus S, Griffiths CEM, Watson REB. Inflammaging and the Skin. Journal of Investigative Dermatology. 2021; Volume 141, Issue 4, Supplement, Pages 1087- 1095


5. Grice EA, Segre JA. The skin microbiome. Nat. Rev.Microbiol. 2011; Apr;9(4):244-53. Erratum in: Nat. Rev. Microbiol. 2011; Aug;9(8):626


6. Roghanian A. Dendritic Cells. British Society for Immunology.


7. Liu K. Dendritic Cells. Encyclopedia of Cell Biology. 2016:741–9. Epub 2015 Aug 20.


8. Alberts B. T Cells and MHC Proteins. Molecular Biology of the Cell 4th Edition. US National Library of Medicine. 1 January 1970


9. Grand View Research. Microbiome Skincare Products Market Size Report, 2023-2030. www.grandviewresearch.com/industry- analysis/microbiome-skincare-market-report


June 2024 PERSONAL CARE


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