SKIN CARE
Nourishing sensitive skin for healthier appearance
M. Carmen Lidón-Moya, Eva Gomez, Jordi Galvez, Albert Soley, Gemma Mola, Raquel Delgado - Lubrizol
Sensitive skin is a condition characterized by heightened responses to stimuli that should not normally cause discomfort. While external factors like temperature and chemicals are known to affect skin sensitivity, the role of nutritional status on skin health and sensitivity is emerging.1
Therefore, understanding the
impact of diet on skin inflammation and ageing is crucial. An unhealthy diet, high in fat and sugar,
induces metabolic stress that leads to skin inflammation and accelerates skin ageing.2,3 This unhealthy diet triggers the release of stressorins, danger alarm signals that bind to RAGE receptors (receptors for Advanced Glycation End Products) on skin cells and other cells. Consequently, this activates the NF-kB signaling pathway, resulting in increased production of pro-inflammatory cytokines.4 Moreover, an unhealthy diet promotes the
formation of Advanced Glycation End products (AGEs) through glycation, further contributing to skin ageing. AGEs also bind to RAGE receptors, activating the proinflammatory NF- kB pathway and amplifying the inflammatory signal.5
In sensitive skin, both stressorins and
the RAGE-NF-kB pathway are upregulated, making them potential targets for reducing inflammation and alleviate the effects of sensitive skin.6,7 Furthermore, an unhealthy diet contributes
to the accumulation of cellular inflammatory garbage, known as ‘garb-aging’. This waste accumulates with age due to the weakening of the cellular clearance mechanisms and serves as a major source of inflammatory stimulus.8
180 160 140 120 100 80 60 40 20 0
Control
Lipofuscin, a component of this biological garbage, is commonly used as a marker of waste accumulation,9
and is associated with
the appearance of brown dark spots on the skin.10,11 Throughout history, thermal waters have been used for their nourishing and soothing properties to promote skin health.12-14 on this knowledge, we have developed
Building
Zenerity™ biotech ingredient, derived from the hydrobiome in Italian thermal springs. Enriched with nourishing minerals, the biotech ingredient minimizes skin inflammation, even when exacerbated by an unhealthy diet. It supports skin health, alleviates the effects of skin sensitivity, and rejuvenates the skin for a youthful appearance.
-31.5% **** *** -18.5%
Methods and results Unless otherwise stated, all statistical analysis in vitro were calculated using an unpaired Student’s t-test, and in vivo, a Student’s t-test or Wilcoxon test after checking the normality distributions by a Shapiro-Wilk test.
Minimizing skin inflammation and ageing in vitro
100 µg/mL Zenerity biotech ingredient concentrate
Metabolic stress
100 µg/mL Zenerity biotech ingredient concentrate
Figure 1: Percentage inhibition of HMGB1 stressorin release (vs Control: *** p < 0.001; vs Metabolic stress: **** p < 0.0001)
www.personalcaremagazine.com Metabolic stress +
The anti-inflammatory capacity of our active ingredient was demonstrated in tubo and in vitro in human epidermal keratinocytes (HEKa), under control conditions or under metabolic stress (by the addition of 20 mM glucose and 0.1 mM palmitic acid to simulate an unhealthy diet high in fat and sugar). HEKa were treated for 24 hours with the active ingredient with or without metabolic
June 2024 PERSONAL CARE
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HMGB1 release (%)
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