ANTI-AGEING
skin, there is less friction at the beginning of a finger’s movement, meaning that the surface is smoother (Merkel cells) than during the movement the surface is perceived as more slippery and less rough (Meissner corpuscle). The decrease in the vibration of receptors
linked to skin’s biomechanical properties (Ruffini and Paccini corpuscle) translates to an improved texture in depth, with greater resistance and less deformation of the tissue meaning a skin with a better density. These data allow us to think that even
if our exploration of Regetaste action mechanism has been mainly focused on the epidermis, some benefits occur in the dermis and mainly on the improvement of biomechanical properties of the extra-cellular matrix. Knowing that in parallel we have also
observed, in vitro, the ability of Regetaste to decrease the expression of the senescence marker Sa-Beta-Galactosidase into fibroblasts, it is a safe bet that the ingredient’s anti-ageing properties extend to the entire skin tissue: epidermis and dermis. This second approach allowed by Touchy
Finger shines a light not only on what the skin looks, but also how it is physically perceived when we touch it. This is a very innovative approach in an era where ever more scientists describe the touch as an important factor for skin homeostasis.
Smoother skin surface shows a brighter and more homogenous complexion Finally, after showing the ability of Regetaste to renovate skin’s surface, in vivo study conducted on 62 volunteers aged between 40- and 65-year-old with dull complexion, shows that one month of treatment with Regetaste significantly improves skin texture by 36% (p<0.01 Student test). In addition, complexion luminosity
increased by 74% (p<0.0001 Student test) and freshness of the complexion by 80% (p<0.0001 Student test). These benefits are visible in Figure 7.
Merkel cell
Meissener corpuscule
63
Figure 5: Tactile receptors in the skin, from: Medical gallery of Blausen Medical 2014. WikiJournal of Medicine 1 (2). doi:10.15347/WJM/2014.010
Conclusion The development of Regetaste for anti-ageing efficacy, and its work on skin’s renovation allowed us to explore all our senses through one organ: the skin. Taste has been addressed through the activation of bitterness receptors, hearing through a smoother skin’s song, touch with the smoother vibrations perceived when we touch a renovated skin, sight through the improvement of the complexion; and smell through the sweet smell of upcycling apple pomace used for the development of this innovative raw material. This development and its associated
demonstrations confirm that skin is a sensory organ, connected with all senses. This is the first time for an active ingredient as sensoriality was exclusively addressed by functional ingredients of formulas. Regetaste paves the way of consideration of all senses in cosmetic strategies.
PC corpuscule Ruffini corpuscule Paccini
References 1. Pensé-Lhéritier AM, Recent developments in the sensorial assessment of cosmetic products: a review. Int. Journal of Cosmet. Science. Volume37, Issue 5, October 2015, Pages 465-473.
https://doi.org/10.1111/ics.12223
2. Shirata NMF. Importance of texture and sensorial profile in cosmetic formulations development. Surg. Cosmet. Dermatol. 2016;8(3):223-30
3. Chung MG, Kim Y, Cha YK, Park TH, Kim Y. Bitter taste receptors protect against skin aging by inhibiting cellular senescence and enhancing wound healing. Nutr. Res. Pract. 2022; v.16(1),1149886
4. Wölfle U, Elsholz FA, Kersten A, Haarhaus B, Müller WE, Schempp CM. Expression and Functional Activity of the Bitter Taste Receptors TAS2R1 and TAS2R38 in Human Keratinocytes. Skin Pharmacol. Physiol. (2015) 28 (3): 137–146
-5.90%
-5.40%
-5.40% -6.20%
Figure 6: Variation of the vibration levels of skin’s mechanoreceptors after two weeks treatment with Regetaste
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Figure 7: Observation of homogeneity and brightness of the complexion before (left) and after (right) four weeks of treatment with Regetaste
January 2024 PERSONAL CARE
% variation versus D0
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