ADAPTOGENS 47 Untreated EnergiNius 0.5%


+84% ****


Figure 4: Elastin synthesis in a monolayer culture of fibroblasts treated with the active - **** p < 0,0001 The extract encompasses around twenty


discernible molecules, including minerals, sugars, amino acids, and withanolids. Notably, withanolids are rare in the plant world. They are only synthesized by a few plants of the Solanaceae genus, with Withania somnifera being the richest specie (qualitatively and quantitatively).


Energizing power of ashwagandha extract demonstrated on skin cells The ashwagandha extract has undergone


a comprehensive series of in vitro tests to unveil its ability to revitalize the skin’s energy levels. It has demonstrated its capacity to aid fibroblasts in combating the detrimental effects of AVL and, in turn, rejuvenating their ability to synthesize key matrix proteins. The extract’s efficacy extends to both the


genomic and cellular dimensions. It fights against the decrease of gene expression related to mitochondria and actin cytoskeleton in fibroblasts exposed to AVL. It thus protects the transcriptome of dermal fibroblasts against


the damaging effects of AVL and consequently, maintains the dermis health after such a stress. It maintains the integrity of the


mitochondrial network, preventing its fragmentation and ensuring the full restoration of ATP production. While cells under light stress exhibit a


highly fragmented mitochondrial network with only small bright dots, treatment with this active ingredient results in the detection of thin mitochondrial filaments, a testament to its protective qualities (Figure 2). Notably,


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January 2024 PERSONAL CARE


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