94 EYE AREA CARE
Figure 2: VISIA-CR standard lighting image of the periorbital region. After 6 weeks of treatment with a phytoglycogen cream, wrinkles are visibly reduced.
Butryospermum parkii (shea) butter, cetyl alcohol, dimethicone, sorbitan stearate, stearyl alcohol, xanthan gum, phenoxyethanol, sorbic acid, caprylyl glycol, tocopherol acetate, and triethanolamine. The number of volunteers in each treatment group ranged from 30- 32, with a total of 93 participants in the study. To evaluate the effect of each treatment on the skin, volunteers were examined by an expert grader. Parameters related to the appearance of aged skin were assessed globally on a 10 point scale after the one week washout period (baseline) and 6 weeks after treatment. Parameters included: overall appearance, fine lines, coarse wrinkles, smoothness (tactile), smoothness (visual), hyperpigmentation, clarity, evenness of skin tone, and firmness. Facial images were also captured at these time points using a VISIA-CR imaging system.
Results and discussion Clinical study
The average change in evaluated parameters between the baseline and week 6 was calculated for each treatment group, shown in Figure 1. The average change between the baseline and week 6 for the 0.1% and 0.3% phytoglycogen groups was greater than in the placebo group for all grading parameters. To quantify these differences, the percent improvement over the placebo was calculated for the 0.1% and 0.3% phytoglycogen groups and is summarised in Table 1.
A binomial signed test was used to
determine the statistical significance of the change in parameters when considered collectively. The average change in both the 0.1% and 0.3% groups was greater than the placebo in all 9 grading parameters, indicating a statistically significant improvement (p = 0.004). The 0.3% phytoglycogen group outperformed the
PERSONAL CARE EUROPE
Table 1: Percent improvement of each mean grading parameter over the placebo after 6 weeks of treatment. Grading Parameter
Overall appearance Fine lines
Coarse wrinkles
Smoothness – tactile Smoothness – visual Hyperpigmentation Clarity
Evenness Firmness
0.1% phytoglycogen +2.9 % +7.4 % +4.3 % +4.7 % +9.1 % +30.0 % +31.3 % +37.0 % +5.3 %
0.1% group in 8 out of 9 grading categories, also indicating a statistically significant improvement (p = 0.02). These results demonstrate that both 0.1% and 0.3% phytoglycogen applied in a topical formulation are effective in improving visible signs of ageing in the skin, and that 0.3% is a more effective dose. VISIA-CR images reflect these results, and demonstrate the improvement in the appearance of fine lines and wrinkles around the eyes. An example of this effect is shown in Figure 2 for a volunteer from the 0.1% phytoglycogen treatment group. After 6 weeks of treatment, crow’s feet wrinkles are visibly reduced.
Conclusion
Phytoglycogen is an effective anti-aging ingredient that can visibly diminish the appearance of crow’s feet wrinkles after 6 weeks of treatment. Chemically identical to the glycogen stored in the body’s cells as a source of energy, the mechanism behind this affect can be understood through previously reported in vitro studies demonstrating increased cellular growth and HA and collagen production. Suitable for the sensitive skin around the eye area, phytoglycogen can be used in eye care formulations to improve the look and feel of the skin as well as to improve the appearance of wrinkles in this area.
PC
0.3% phytoglycogen +17.6 % +21.0 % +21.7 % +36.0 % +36.4 % +85.0 % +39.6 % +55.6 % +5.3 %
References 1 Wright ET, Shellow WVR. The histopathology of wrinkles. J. Soc. Cosmet. Chem. 1972; 24: 81-85.
2 Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the aging skin. Adv. Wound Care. 2013; 2 (1): 5-10.
3 Ahmadraji F, Shatalebi MA. Evaluation of the clinical efficacy and safety of any eye contour pad containing caffeine and vitamin K in emulsisfied emu oil base. Adv. Biomed. Res. 2015; 4: 10.
4 Miki C, Dewitte-Orr S, Foldvari M, Moore M. Anti-aging properties of phytoglycogen. Household and Personal Care Today. 2018; 13 (2): 26-28.
5 Halprin KM, Ohkawara A. Glucose and glycogen metabolism in the human epidermis. J. Invest. Dermatol. 1966; 48 (1): 43-50.
6 Grossutti M, Miki C, Dutcher JR. Phytoglycogen nanoparticles: Key properties relevant to its use as a natural moisturizing ingredient. Household and Personal Care Today. 2017; 12 (1): 47-51.
7 Varani J, Dame MK, Rittie L, et. al. Decreased collagen production in chronologically aged skin: Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am. J. Pathol. 2006; 168 (6): 1861-1868.
8 Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology. 2012; 4 (3): 253-258.
September 2018
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