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EYE AREA CARE 93


Periorbital wrinkles reduced by phytoglycogen


n Carley Miki – Mirexus, Canada


The skin undergoes many changes as it ages due to both intrinsic and extrinsic factors. The epidermis thins as the subcutaneous fat layer diminishes, collagen and elastin fibers breakdown and their synthesis rates decline, the skin’s capacity to hold water decreases and sebum production slows - resulting in dryer skin, and cellular turnover rates slow - resulting in dull looking skin.1, 2


These changes make


the skin susceptible to the formation of wrinkles. The sensitive skin around the eyes is especially prone to wrinkling as it is thinner than the surrounding skin with less underlying muscle and fat to support it, as well as a lower collagen and sebum content.3


Because of this, periorbital


wrinkles, often called ‘crow’s feet’, are one of the first places for wrinkles to develop and one of the first visible signs of ageing.3 Phytoglycogen, a stored energy source in plants, is chemically identical to the glycogen found throughout the human body and performs much the same function. The role of glycogen in the skin is not well understood, but evidence of its role in wound healing, moisture retention, and cellular growth have been documented.4-6


Phytoglycogen in the form


of monodisperse, 70 nm diameter particles (measured by dynamic light scattering) have been extracted from non-GMO sweet corn (PhytoSpherix®


, Mirexus Inc.) and have been


1.6 1.4 1.2 1


0.8 0.6 0.4 0.2 0


Abstract


Phytoglycogen is a natural, plant-based form of glycogen, providing energy to cells that can be utilised to increase proliferation and production of important extracellular components. To evaluate the benefits of topically applied phytoglycogen, a clinical study was performed. Volunteers applied a cream containing either 0.1%, 0.3%, or no phytoglycogen (placebo) to their face twice a day for 6 weeks and were assessed by an expert grader at the baseline and after 6 weeks of treatment. The impact of phytoglycogen on crow’s feet wrinkles was evident in facial images taken with a VISIA-CR system.


shown to promote cellular growth, hyaluronic acid (HA) production, and collagen production in vitro.4


When


applied to human skin tissue, fluorescently- tagged phytoglycogen has been seen to penetrate to depths corresponding to the dermal layer.4


This activity suggests a


mechanism by which topically applied phytoglycogen can provide anti-ageing benefits to the skin: when living cells in the dermis take up phytoglycogen, it provides energy to the cells and allows them to proliferate more quickly and produce HA and collagen at an increased rate. These features are important factors in maintaining youthful looking skin, but begin to slow and diminish with age.2, 7, 8


A clinical


study was conducted to validate this effect, and the impact of topically applied phytoglycogen on the visibility of fine lines and wrinkles in the periorbital region was


n Placebo n 0.1%PG n 0.3%PG *


* * * ** * * * ** * * * Overall Appearance Fine Lines Coarse Wrinkles


Smoothness- tactile


Smoothness- visual


*


1.6 1.4 1.2 1


0.8 0.6 0.4 0.2 0


* * * * evaluated by imaging techniques.


Materials and methods Clinical study


A double-blind clinical trial was conducted by Thomas J. Stephens & Associates (Richmond, TX) to evaluate the visible effect of topically applied phytoglycogen. Female volunteers, aged 49-70 years, were randomly assigned to one of three treatment groups where they were given a cream to apply to their entire face twice per day for 6 weeks, following a one week washout period when no skin care products were used. The creams contained the same base formula, but different concentrations of phytoglycogen: either 0.1%, 0.3%, or no phytoglycogen (placebo). In addition to phytoglycogen, each base cream contained water, glycerin, Prunus amygdalus (almond) oil, Persea gratissima (avocado) oil,


n Placebo n 0.1%PG n 0.3%PG


* * * * * ** *


Hyperpigmentation


Clarity


Evenness


Firmness


Figure 1: Average change in expert grading parameters between baseline and week 6 for each treatment group: placebo, 0.1% phytoglycogen (PG), and 0.3% phytoglycogen. * indicates a statistically significant result (p<0.05)


September 2018 PERSONAL CARE EUROPE


Average change from baseline


Average change from baseline


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