ANTI-AGEING


Cyclic peptide to tackle wrinkles’ daily cycle


Laia Farré, Ariadna Grau-Campistany, Andrea Esplugas, Patricia Carulla, Silvia Pastor - LipoTrue


Entropy is the tendency to go from a state of order to an environment of chaos. The circle is a geometric conformation related with organization, order and perfection. Circles are present in nature to maintain order through the formation of cycles. Cycles are crucial in our life to maintain a


routine and, consequently, order. This order is not only present in our life and nature but also in our skin with the wrinkles’ daily cycle, also known as WDC. This cycle is influenced by ‘skintropy’, the chaos in our skin which can lead to premature senescence, causing aged skin.


Skintropy: the chaos in our skin In normal conditions, proteins are synthesized in the endoplasmic reticulum (ER) guided and properly folded by chaperones and released through vesicles. Aged skin can be attributed to various


factors, including stress on the ER and so skintropy. Stress on this organelle is the result of an accumulation and aggregation of misfolded and unfolded proteins. To avoid this, there is the UPR (Unfolded


Protein Response), which is a compensatory mechanism that is activated to avoid the accumulation of unfolded or misfolded proteins. The UPR attempts to restore the


system to an organized state by activating key chaperones, such as BiP (Binding Immunoglobulin Protein) and calreticulin. BiP is also known as the master folding


Basal (Calreticulin in green)


89


regulator of the UPR, which aids in refolding proteins when their folding is not optimal. Calreticulin's function is to ensure the proper protein folding. As we age, this system begins to falter,


chaperone levels decrease, the efficiency of the UPR is impaired, and achieving organization within the ER becomes more challenging, leading to an accumulation of misfolded proteins


0.005 mg/mL cyclic peptide (Calreticulin in green)


and ultimately prompting cell apoptosis. This translates into a disorganization in our skin. To return this order and harmony of a young


skin, Poptide™, a cyclic peptide, was developed by LipoTrue to improve the folding protein process in the ER to minimize misfolded protein accumulation that consequently leads to cell apoptosis. Circles are simple and resistant geometric


conformations, which is why in nature we can find several cyclic peptides due to their favourable characteristics such as higher stability and low toxicity. This cyclic conformation provides order and structure to our skin.


Wrinkles’ daily cycle There is a cycle in our skin that may be unknown to many of us, what we call the wrinkles’ daily cycle or WDC. This phenomenon explains the fluctuation in the appearance of our skin in the morning and in the evening. Wrinkles become more pronounced as


www.personalcaremagazine.com Figure 1: Fluorescent images of calreticulin levels in HEKa, showing calreticulin in green


the day progresses due to facial expressions, gestures, lack of hydration, exposure to external factors harmful to our skin throughout the day, and our upright position where the effects of gravity work against us. This is why, in the evening, the skin's appearance is more wrinkled and with less elasticity or firmness. During the night, the machinery to recover all structures damaged during the day starts to


October 2024 PERSONAL CARE


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