34 ANTI-POLLUTION
18 16 14 12 10 8 6 4 2 0
Placebo CP Complex (3%) Figure 7: CP Complex leads to a clear improvement of skin barrier function
volunteers (all female, 36–63 years old, average: 53.6). Test products (CP Complex (3%) and corresponding placebo) were applied twice daily on the hemiface for 28 days. Skin barrier function was determined with Tewameter® TM 300 (Courage + Khazaka electronic GmbH, Germany). Barrier function at the beginning of the study was set at 0%. Result Both formulations were able to improve barrier function, but the effect of the formulation containing CP Complex was more than double that of the corresponding placebo formulation (Figure 7).
Subclinical inflammation Inflammatory processes are ubiquitous in facial skin. These processes, however, are not always visible or directly perceivable. However, these processes might still have negative outcomes for the skin in the long run. An elegant way of visualizing these
processes is based on the Antera 3D technology (Miravex Limited, Ireland), which allows visualization and quantification of blood flow in the skin (‘hemoglobin average level’). Blood flow in the skin is an important indicator of inflammatory processes. Thirteen volunteers (7 female, 6 male)
were enrolled in the study. They were 35–64 years old, average: 52.4. Hemoglobin average level at t = 0 of skin before treatment with CP Complex: >32.
Result
The skin of less than half of the volunteers treated with placebo showed a significant
12 10 8 6 4 2 0
Placebo Figure 9: CP complex improves skin elasticity PERSONAL CARE October 2024 CP Complex (3%)
90 80 70 60 50 40 30 20 10 0
Placebo CP Complex (3%) Figure 8: CP Complex clearly reduces subclinical inflammation in skin
reduction of hidden inflammation, whereas CP Complex reduced hidden inflammation in almost 90% of the cases (Figure 8). As previous in vivo studies looking at skin
resilience and skin barrier function showed, the formulation containing CP Complex was almost twice as effective as the same formulation without CP Complex (placebo).
Skin firmness and elasticity In maintaining full functionality, skin also constantly manages its mechanical properties. A study was performed on 16 volunteers (9 female, 7 male), 36– 64 years old, average: 54.1.
Determination of facial skin elasticity was based on R2 as obtained from measurements with a Cutometer® dual MPA 580 (Courage + Khazaka electronic GmbH, Germany). R2 at t = 0 of skin before treatment with CP Complex: <63. Skin elasticity at t = 0 was set at 0%. Another study was performed on facial skin
of 10 volunteers (6 female, 4 male), 35–64 years old, average: 51.5. Based on R0 as determined with Cutometer® dual MPA. R0 at t = 0 of skin before treatment with CP Complex: >0.76. Skin firmness at t = 0 was set at 0%.
Results Facial skin elasticity, but especially firmness were strongly increased after treatment with CP Complex (Figures 9 and 10).
Conclusions CefiraProtect CLR (CP Complex) offers a promising advanced skin care solution aimed at addressing the challenges posed by the
20 15 10 5 0 Placebo CP Complex (3%) Figure 10: CP Complex strongly improves skin firmness
www.personalcaremagazine.com
exposome on facial skin. As highlighted, the skin is continually exposed to a myriad of external stressors that contribute to oxidative stress, protein oxidation, and subsequent skin ageing. Traditional antioxidants in skin care formulations often lack stability and can inadvertently exacerbate oxidative stress. CP Complex, inspired by the health
benefits of kefir and containing hero- ingredient kefiran, is harnessed through innovative vegan cell-based fermentation technology and effectively supports the skin’s antioxidative defences. Extensive in vitro, ex vivo, and in
vivo studies substantiate the efficacy of CP Complex in reducing free radicals, improving skin’s antioxidative potential, and, importantly, minimizing protein oxidation. The studies demonstrate that CP Complex not only enhances the skin’s barrier function but also significantly reduces subclinical inflammation, thereby promoting a more resilient and robust skin structure. The observed improvements in skin firmness and elasticity further affirm CP Complex’s role in maintaining youthful and healthy skin. As a daily skin care companion, CP
Complex stands out by aligning with the growing consumer demand for sustainable, vegan, and environmentally friendly products, making it a comprehensive solution for modern skin care needs. Its incorporation into facial skin care routines can provide effective protection and rejuvenation, preserving skin health and appearance in the face of relentless environmental challenges.
PC
Improvement of barrier function (%)
Improvement of barrier function (%)
Improvement firmness (%)
% volunteers showing redness reduction
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