82 PEPTIDES
SENESCENT
8 days incubation with MM +10 µg/ml
Centella Reversa™
YOUNG
Figure 7: Microscopic images of young and aged fibroblasts treated with the Centella asiatica biotechnology active
rejuvenates skin complexion, achieving a real appearance of four years of rejuvenation.
In vivo biomechanical properties and skin wrinkles Double-blind study versus placebo was conducted with 20 volunteer women aged between 51-and 59. Two applications of Centella asiatica biotechnology active at 2% were applied at the crow’s feet. Measurements were obtained at 28-56 days. The Centella asiatica biotechnology active
significantly increased the skin firmness at 28 and 56 days up to 36% and 46% respectively compared to baseline. Regarding the skin elasticity parameter, the Centella asiatica biotechnology active significantly increased the skin elasticity at 28 and 56 days by up to 21% compared to baseline (Figure 8). Once calculated the Rejuvenation Index (RI) based in the elasticity parameter and comparing with the reference group of young volunteers (20- 25 years), it could be concluded that the older group of volunteers (51-59 years) were: ■ 28 days: RI= 12%, equivalent to 3.6 years younger ■ 56 days: RI= 14%, equivalent to 4 years younger Regarding the clinical evaluation of intensity
of wrinkles, reduced the intensity of wrinkles gradually, being significantly different from the placebo at 56 days with a 9.3% of wrinkle reduction.
In vivo and facial complexion analysis Product’s ability to improve the characteristics of facial skin under three types of lighting was tested. Measurement of 6 different parameters by VISIA Canfield Imaging Systems: visible stains, texture, red areas, wrinkles, porphyrins and pores.15
■ Wrinkles: 34% and 40% respectively ■ Texture: 48% and 53% respectively ■ Pores: 51% and 57% respectively ■ Visible stains: 17% and 21% respectively ■ Red areas: 45% Areas and 52% respectively ■ Porphyrins: 68% and 76% respectively
Conclusion Considering the precedents, the previous results show that genuine natural plant peptides, produced entirely in an eco-sustainable and easily scalable innovative plant technology platform, have a proven growth factor-like effect. Vytrus has harnessed Centella Reversa, a 100% natural and COSMOS-approved innovation, to create an active ingredient derived from natural Centella peptides. This opens up exciting opportunities in both cosmetic and dermatological applications, including well-ageing, anti-wrinkle, hair growth stimulation, skin regeneration, and wound healing.
This unique Centella asiatica product
offers a range of benefits, including firming, anti-sagging, anti-wrinkles, reversion of cellular senescence, and the protection of telomeres, making it the first plant alternative to animal growth factors.
Areas of application: face, measurements
at 28-56 days; two daily applications by the volunteers (52-63-year-old women) Centella asiatica Callus Conditioned Media 2%, following the instructions of the study centre. The Centella asiatica biotechnology active
significantly reduced compared to baseline at 28 and 56 days all the parameters (Figure 9):
PERSONAL CARE November 2023
20 18 16 14 12 10 8 6 4 2 0
***p<0.001
+16% ***
***
+19% ***
This scientific innovation brings a new
approach to regenerative peptides and well- ageing markets and a novel discovery in the fascinating plant peptides universe. This new category of biotechnology-based
active ingredients offers cosmetic formulations new pathways to revert cell senescence and enhance the inherent regenerative properties of skin with a sustainable solution based on plant biotechnology: ■ Skin ageing treatment and prevention ■ Firming, anti-sagging & anti-wrinkles treatments ■ Facial treatments, neck, decolleté & hands ■ Cica treatments ■ Skin imperfections treatments ■ Rich nutritive creams and lotions (day & night) ■ Natural treatments (serums, gel-creams, creams & masks)
PC
References 1. Lo JH, Chen TT. Production of bioactive recombinant human Eb-peptide of pro-IGF-I and identification of binding components from the plasma membrane of human breast cancer cells (MDA-MB-231). Exp. Cell Res. 2018; Jan, 235-243
2. Xiong R, Chen J, Chen J. Secreted expression
Placebo cream ■ Cream with 2% Centella Reversa ■ ***p<0.001
9 8 7 6 5 4 3 2 1
0 T=28D T=56D T=28D T=56D
Figure 8: A. Mean values of the parameter Ue reduction obtained with placebo and the Centella asiatica biotechnology active, at 28 and 56 days. A decrease in Ue parameter indicates an increase in skin firmness. B. Mean values of the parameter Ur/Uf increase obtained with placebo and the Centella asiatica biotechnology active, at 28 and 56 days. Increases in Ur/Uf indicate improved elasticity
www.personalcaremagazine.com
+7% ***
***
+8% ***
% Skin firmness increase vs T = 0D
% Skin firmness increase vs T = 0D
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