PEPTIDES
Unlocking the potential of plant-derived peptides
Òscar Expósito, Monika Buchholz, Alejandro Guirado, Tarik Ruiz, Mireia Perez, Maria Mas, Ana Gallego, Sara Laplana - Vytrus Biotech
In the current market landscape, a significant industry revolves around oligopeptides, extensively used in both cosmetics and pharmaceuticals. However, these peptides typically originate from human sources, and their production methods often involve substantial costs or genetic modification.1,2 Recent tests have revealed the remarkable
potential of plant-derived oligopeptides, closely resembling their human counterparts, in stimulating the regeneration of human skin cells through their growth factor effect. Drawing on the biotech company’s internal
expertise, parallels in tissue regeneration processes between plants and animals have been identified. Vytrus has pinpointed a range of small signaling peptides known as plant oligopeptides involved in the regeneration or healing processes. Leveraging the innovative growth factor
control development process, Vytrus Biotech has successfully identified, produced, and concentrated the inaugural generation of purely plant-derived peptides known as Phyto-Peptidic Fractions™ (PPF), a patented technology. These PPF are derived from an optimized culture of totipotent cells, also known as plant stem cells, capable of regenerating an entire plant from a single cell.3-5 The exceptional regenerative properties of
plant totipotent cells can be primarily attributed to these PPF, marking them as the pioneering cosmetic assets adept at preserving the skin’s regenerative potential. Abundant in plant- based growth factors, transcription factors, and epigenetic modulators, these PPF offer substantial promise for a broad spectrum of
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cosmetic and dermatological applications. These applications span from stimulating hair
growth and combating ageing and wrinkles to fostering skin regeneration, expediting wound healing and beyond.
Plant peptides with inherent enhanced efficacy Vytrus focused on Phyto-Peptidic fractions of
ABSTRACT
+ 10% FBS Positive control
MM
Asiaticoside Acid*
+ 250 µM MM Centellosides + 0.2 µg/ml MM + 6 µg/ml MM Plant extracts Figure 1: Centella plant peptides regenerative efficacy6,7
www.personalcaremagazine.com November 2023 PERSONAL CARE + 100 µg/ml MM Centella asiatica extract** + 0.16 µg/ml MM + 0.52 µg/ml MM Centella Reversa
Phyto-Peptidic Fractions
Vytrus internal utilizes expertise in plant regeneration processes to further exploit the potential of totipotent plant cell cultures potential. Small signaling peptides (plant oligopeptides) have been identified to have wound healing properties a growth factor effect. These peptides exhibit high homology with animal growth factors and participate in similar physiological cell processes. It has been shown that they produce a remarkable growth factor effect on senescent human dermal fibroblasts, thereby offering significant potential for the rejuvenation of human skin through a growth factor-like mechanism. Preliminary test results indicate that these specific peptide fractions have the capacity to reverse the senescence phenotype of senescent fibroblasts, significantly inhibiting the senescence of cells and promoting cell proliferation with high efficiency. These outcomes could provide opportunities for both cosmetic (anti-ageing) and dermatological (skin regeneration, wound healing) applications in which a natural plant peptide is utilized.
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