ANTI-AGEING
TABLE 1: COMPARATIVE SUMMARY OF THE ANTI-INFLAMMATORY & ANTIOXIDANT ACTIVITY OF CBG, CBD & THEIR BLENDS Summary of results
CBG Cell-Free Antioxidant Capacity6 Cell-Based Antioxidant Capacity6 UVA Inflammation (IL-6)6 UVB Inflammation (TNF-α)6 UVB Inflammation (IL-8) Lipid Peroxidation (4-HNE) ++
+++ +++ +++ +++ ++
References 1. Masakazu Y, Nakamura T, Kato M, Ishioka T, Kozawa K, Wakamatsu K, Kimura H. Release of cytokines/chemokines & cell death in UVB-irradiated human keratinocytes, Hacat. Cell. Biol. Int. 2008. 32(11): 1405-1411. doi:10.1016/j.cellbi.2008.08.011
2. Endoh I, Di Girolamo N, Hampartzoumian T, Cameron B, Geczy CL, Tedla N. Ultraviolet B irradiation selectively increases the production of interleukin-8 in human cord blood-derived mast cells. Clin.
CBD +
+++ ++ ++
+++ ++
CBG+CBD N/A N/A N/A N/A
+++ ++
Exp. Immunol. 2007. 148(1): 161-167. doi:10.1111/j.1365-2249. 2007.03332.
3. Zhuang Y, Lyga J. Inflammaging in skin & other tissues - the roles of complement system & macrophage. Inflamm. All.-Drug Targets, 2014. 13(3): 153-161. doi:10.2174/1871 528113666140522112003
4. Haque A, Woolery-Lloyd H. Inflammaging in dermatology: A new frontier for research. J. Drugs Derm. 2021. 20(2): 144-149. doi:10.36849/jdd.5481
5. Chajra H, Delaunois S, Garandeau D, Saint-
81
Ascorbic Acid
+++ + +
N/A
+++ +++
Clobetasol Propionate
N/A N/A N/A + N/A N/A
Auret G, Meloni M, Jung E, Frechet M. An efficient means to mitigate skin inflammaging by inhibition of the NLRP3 inflammasome & Nfkb pathways: A novel epigenetic mechanism.
Genel.Fr. 2019.
6. Perez E, Fernandez JR, Fitzgerald C, Rouzard K, Tamura M, Savile C. In vitro & clinical evaluation of cannabigerol (CBG) produced via yeast biosynthesis: A cannabinoid with a broad range of anti-inflammatory & skin health- boosting properties. Molecules. 2022. 27(2): 491. doi:10.3390/molecules27020491
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June 2022 PERSONAL CARE
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