TESTING


27


Collagen I - Backbone of the tissue architecture – Fibril-forming


and/or immune cells), and 3D models (skin explants or 3D reconstructed models (epidermis or full thickness). To study regeneration or oxidative effects, the use of modified models obtained with genetic modifications or other methods can also be relevant. One of the main interests using the


preclinical assays is linked to the importance of the barrier function and extra-cellular matrix study. When functional, the skin regulates the exchanges between the external and the internal environment, preventing


Collagen IV - Major component of the dermal- epidermal junction


water loss or protecting the body against noxious substance absorption, microorganism intrusion or physical trauma. The skin therefore acts as a barrier. Skin barrier function mainly relies on


the stratum corneum (SC), the outermost layer of the epidermis. SC is formed by ultra-differentiated, metabolically unactive and tightly associated keratinocytes called corneocytes. These are embedded in a lipid- rich matrix and constantly renewed thanks to undifferentiated keratinocytes which proliferate in the basal layer of the epidermis


Elastin – Component of the extra-cellular matrix involved in the skin elasticity properties


and progressively differentiate while migrating towards the SC. Many factors (genetic, microorganisms,


physical trauma, chemicals, etc.) may impair skin barrier function leading to excessive water loss, microorganism infection, skin inflammation, pruritus, and various diseases including psoriasis and atopic dermatitis. The constant renewal of the epidermis


allows the skin barrier to remain functional. However, physical, chemical, thermal, microbial, or immunological insults can impair this barrier function, leading to the disruption


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June 2022 PERSONAL CARE


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