TRENDING TECHNOLOGIES
reported earlier in the sanitizing dysbiosis study with the following changes occurring for the purpose of this study.13
This study
employed the use of six individuals (N=6) who all signed informed consent to participate in the study. All the participants had healthy,
undisrupted inner volar forearm skin and had not taken antibiotics or used any type of potential sanitizing or exfoliating products two weeks prior to participation in the study. Both arms of each participant were used that allowed inclusion of both a test site and a control, untreated, site on each arm that allowed for a total of n=12 inner volar forearms to be examined (Figure 2). Prior to participating in the study, everyone
was instructed to do their morning washing but to not use soap or scrub on their inner volar forearms to rinse the arms with warm water and to not apply any types of products to their arms for the duration of the study.
CHARM ATP biofluorescence unit For these studies, a NovaLum VX-II ATP analyzer from Charm Sciences, Inc. of Andover, Massachusetts was employed to measure ATP biofluorescence.13
The company also
provides PocketSwab Plus swabs. A picture of a PocketSwab is shown in Figure 3. PocketSwab Plus is a self-contained unit that
has a swab stored until use in a sterile chamber. When ready for use, the swab is withdrawn from the unit and is applied to the surface being tested using specific directions offered by the company, which includes a swabbing pattern that requires approximately 16 square centimetres of surface while rotating the swab and applying pressure to the surface. The resulting swab is then inserted back into the unit, and with a twisting screw motion is thrust through a thin foil membrane that houses an oxidizing fluid. The tip of the swab and the oxidizing fluid drop into the clear chamber at
59
Control/Baseline Site Test Site
Test Site Control/Baseline Site
Figure 2: Inner volar forearm testing sites
Figure 3: CHARM PocketSwab
the bottom of the device. The device houses a small tablet that contains a luciferin dye that is activated by the oxidizing fluid and a luciferase enzyme pellet that has been designed to detect ATP.
The device fluoresces in accordance with the amount of ATP present on the swab. The resulting activated unit is placed into the NovaLum ATP analyzer shown in Figure 4. The device then measures the amount
of luciferin biofluorescence and reports the values in relative fluorescent units (RFU), which can be recorded for testing purposes. Measurements were made at a room temperature of 22-24°C and an RH of
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approximately 45-50%, and each participant equilibrated to the room for 15 minutes prior to measurements being taken. One site on the inner volar forearm served as an untreated control/baseline measuring site. The other adjacent site served as the site of
product application. The sites were alternated on each arm to minimize variability of site microbial load. Measurements were made at two time points after application of the cream: 20 minutes and 60 minutes. Statistical analysis The RFU for each timepoint were collected and averaged. The results were then compared between the two timepoints and the control
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