ANTI-AGEING
Impact of neuroprotective action on fibroageing In spite of an observed drop in the viability of fibroblasts exposed to neuroaeging messengers, through its neuroprotective action, the new hydrolysed algin provides 131% protection against decreased fibroblast viability that had been induced by neuroageing (Fig. 5). By protecting neurons against neuroageing, the new hydrolysed algin re-establishes a healthy communication between nerve endings and fibroblasts, thereby protecting dermal cells from fibroageing. Under these conditions, collagen and
elastin synthesis are once again optimal, with respective variations of +405% and +832% as compared to synthesis obtained under conditions of neuroageing (Fig. 6).
Neuroprotection: a new key to treating the deep wrinkles of people over sixty The benefits of this neuroprotective approach were evaluated on a panel of 20 volunteers, ages 62 to 74. The depth and extent of crow’s foot wrinkles, as well as skin roughness, were evaluated before and after 28 and 56 days of twice-daily application of a cream containing 1.5% new hydrolysed algin. The study showed a visible decrease in the volume and extent of wrinkles from 28 days and significant variations after 56 days of treatment (Figs.7 & 8). In a similar manner, skin roughness
a 0 –5
–10 –15 –20 –25 –30
–8% –11.5% –14% ** 2 D28 D56
Figure 6: Impact of neuroprotective action of Neuroguard on the synthesis of extra-cellular matrix. Proteins. Visualisation of collagen synthesis (green fluorescence) in cultures of fibroblasts exposed to messengers of neurons submited to neuroageing a) without, or b) with 0.15% Neuroguard. Visualisation of elastin synthesis (red fluorescence) in cultures of fibroblasts exposed to messengers of neurons submited to neuroageing c) without, or d) with 0.15% Neuroguard.
was less after 28 days, with a significant variation after 56 days of treatment.
Conclusion Neuroguard revolutionises neurocosmetics by directly targeting the ageing of nerve endings. Its neuroprotective action blocks neuroageing and re-establishes a healthy communication between nerve endings
b D28 D56
and fibroblasts, thus protecting dermal cells from premature ageing. Under these conditions, collagen and elastin synthesis are reactivated, deep wrinkles are diminished and skin texture is smoother. With an action focused on neuroageing, Neuroguard provides an appropriate and well-targeted answer for treating wrinkles in individuals aged sixty and older.
PC
References 1
Prigg M. How your skin is smarter than you think: Researchers find neurons can carry out advanced calculations to tell the brain exactly how we are being touched. MailOnline 2014: 1 September (
http://tinyurl.com/nzz362r).
Bourdet J. When the touch declines. CNRS Le Journal 2014: 3 April (online) [in French]. (
https://lejournal.cnrs.fr/articles/quand-le- toucher-decline).
–25% *** **p<0.01; *** p<0.001 Student’s t-test
Figure 7: Effect of 1.5% Neuroguard on both a) volume, and b) area of crow’s feet wrinkles after 28 and 56 days treatment.
D0 D28 D56
3 Cárdenas-Aguayo MDC, Silva-Lucero MDC, Cortes-Ortiz M et al. Physiological role of amyloid beta in neural cells: The cellular trophic activity. In: Heinbockel T ed. Neurochemistry. InTech, 2014: Ch 9.
4 Selective detection of sAPP and amyloid peptides using Alpha Technology. Perkin Elmer (online) (
www.tinyurl.com/ok47433).
5
Sheng B, Gong K, Niu Y et al. Inhibition of γ-secretase activity reduces A production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer’s disease. Free Radic Biol Med 2009; 46 (10): 1362-75.
6
Figure 8: Visualisation of the effect of 1.5 Neuroguard on crow’s feet wrinkles, using fringe projection.
Obregon D, Hou H, Deng J et al. Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation. Nat Commun 2012; 3: 777.
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