SKIN PROTECTION
n Active (2260115.A/IBRN2981-1) n Placebo (2260115.B/IBRN2981-2)
1.0 0.0 –1.0 –2.0 –3.0 –4.0 –5.0 –6.0
0.2 0.2
–3.0 NS
–5.5 *
Day 14 Figure 13: Visible spots area variation.
Visia Use of our active allows us to observe: l A moderate effect on wrinkle count, with statistical significance vs. baseline and placebo.
l A small but statistically significant improvement in UV spots count.
l Small but statistically significant improvement in visible spots count.
Skin firmness (Cutometer) Significant improvements vs. baseline were measured at D14 and D28, with statistical break vs. placebo at D28.
Self-evaluation questionnaire The active brought about stronger improvements vs. placebo (with statistical significance) in terms of skin tone, skin radiance, occurrence of spots, skin sensitivity, wrinkles, visible skin health, and visible skin youthfulness.
Conclusion In many of the cases, the effects observed are suggested or already visible at D14, and become stronger and/or statistically significant at D28. This supports a repair- enablement mechanism, where the active intervenes to relieve some of the chronic toxic stress on the skin, thus allowing it
Day 28
0.45 0.40 0.35 0.30 0.25 0.20 0.15 0.10 0.05 0.00
n Active (2260115.A/IBRN2981-1) n Placebo (2260115.B/IBRN2981-2)
* 0.292 0.278 0.206
* 0.195
*
* 0.205 0.220
Day 0 Figure 14: Firmness evolution.
to gradually return to a more favourable homeostasis state – translating into visible beauty benefits.
References 1
2
A guide to medicinal plants in North Africa. Malaga: IUCN Centre for Mediterranean Cooperation, 2005.
Youssef SA, Ibraheim ZZ, Attia AA. Flavonoids from Asteriscus pygmaeus (DC). Cross & Grown in Egypt. Bull Pharm Sci Assiut Univ 1995; 18 (1): 33-38.
3 Fahmy H. J Environ Sci 2003; 26: 307. 4
Benchelah A-C, Bouziane H, Maka M. Fleurs du Sahara, arbres et arbustes, voyage au coeur de leurs usages avec les Touaregs du Tassili. Phytothérapie 2004; 6: 191-7.
5
Znini M, Cristofari G, Majidi L et al. Antifungal activity of essential oil from Asteriscus graveolens against postharvest phytopathogenic fungi in apples. Nat Prod Commun 2011; 6 (11): 1763-8.
6
Abouri M, El Mousadik A, Msanda F et al. An ethnobotanical survey of medicinal plants used in the Tata Province, Morocco. Int J Med Plant Res 2012; 1 (7): 099-123.
7 Sarg T et al. Fitoterapia 1994; 5: 179.
n Active (2260115.A/IBRN2981-1) n Placebo (2260115.B/IBRN2981-2)
* Q15
n Active (2260115.A/IBRN2981-1) n Placebo (2260115.B/IBRN2981-2)
0.0 –5.0 –10.0 –15.0 –20.0 –25.0 –30.0
*Q14 –9.5 Q16 8 PC
Cristofaria G, Zninib M, Majidib L et al. Chemical diversity of essential oils from Asteriscus graveolens (Forssk.) Less.:Identification of cis-8- acetoxychrysanthenyl acetate as a new natural component Chem Biodiv 2012; 9: 727.
9 Sarg, TM et al. Tetrahedron 1985: 41 (2): 309. 10 Akssira et al. Tet Lett 2006; 47: 6719. 11 Ahmed A et al. J Nat Prod 1991; 54: 1092. 12 Alilou H, Bencharki B, Hassani LMI, Barka N. Phytochemical screening and spectroscopic identification of Asteriscus graveolens subsp odorus flavonoids [in French]. Afrique Sci 2014, 10 (3), 316-328.
13 Akssira M et al. J Nat Sci Res 2014: 4 (10): [online].
14 Askarne L, Talibi I, Boubaker H et al. Use of Moroccan medicinal plant extracts as botanical fungicide against citrus blue mould. Lett Appl Microbiol 2013; 56 (1): 37-43.
15 Znini M, Cristofari G, Majidi L et al. Antifungal activity of essential oil from Asteriscus graveolens against postharvest phytopathogenic fungi in apples. Nat Prod Commun 2011; 6 (11): 1763-8.
16 Zilberg D et al. Isr J Aquacult 2005, 57 (2): 71. 17 Majidi L et al. Int J Electrochem Sci 2012; 7: 3959.
Q1
85.0 65.0 45.0 25.0 5.0
* Q13 –15.0 Q2 * Q3 * Q4 *
Day 14
Day 28
Q5
Q12 –23.4
–27.5 NS
Day 14 Figure 15: Firmness variation. 60 PERSONAL CARE September 2015
–26.5 *
Day 28 * Q10 Q8 Q9 Q11 Q7 Figure 16: Self
assessment: variation against D0:28 days.
Q6
Change (%)
Change (%)
Firmness (AU)
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