MARINE INGREDIENTS
discovered. The active obtained from the microalga Tisochrysis lutea proved to be able to convert lipid-storing adipocytes into lipid-burning beige adipocytes as well as to increase the thermogenic activity of subcutaneous fatty tissue. These actions on the human body are palpable thanks to the in vitro results showing an increase of the thermogenesis process, and to the in vivo significant efficacy in the reduction of the body circumference in both men and women by decreasing the thickness of subcutaneous adipose tissue.
The studied active is the perfect solution
for the demands of modern life, where consumers are looking for new ways to inject self-care into their daily routines, boosting wellbeing and helping their natural beauty shine through. With its proven metabolism-stimulating properties, and its biotechnological and sustainable marine origin, the active meets the demand for energising, confidence-boosting body care, as well as placing the planet’s most delicate and important ecosystems at its centre.
PC
References 1. Zhang X, Spiegelman D, Baglietto L, Bernstein L, Boggs DA, Van Den Brandt PA Buring JE, Gapstur SM, Giles GG, Giovannucci E. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. Am J Clin Nutr 2012;95(3):713–25.
2. Leermakers ET, Darweesh SK, Baena CP, Moreira EM, Van Lent DM Tielemans MJ, Muka T, Vitezova A, Chowdhury R, Bramer WM. The effects of lutein on cardiometabolic health across the life course: a systematic
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Figure 10: Measurement of thickness of subcutaneous fat layer.
review and meta-analysis. Am J Clin Nutr 2016;103(2):481–94
3. Zapata M, Garrido JL. Ocurrence of phytylated chlorophyll c in Isochrysis galbana and Isochrysis sp. (clone T/ISO) (Prymnesiophyceae). Journal of Phycology. 1997; 33(2):209-21
4. Obata M, Taguchi S. The xanthophyll-cycling pigment dynamics of Isochrysis galbana
D5
(Prymnesiophyceae) during light–dark transition. Plankton Benthos Res. 2012; 7(3): 101–110.
5. Barbe P, Stich V, Galitzky K, et al. In Vivo Increase in b-Adrenergic Lipolytic Response in Subcutaneous Adipose Tissue of Obese Subjects Submitted to a Hypocaloric Diet. Journal of Clinical Endocrinology and Metabolism. 1997; 82(1):63-69.
6. Ouellet V, Labbé SM, Blondin DP, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. The Journal of Clinical Investigation. 2012; 122(2):545-552.
7. Cannon B, Nedergaard J. Yes, even human brown fat is on fire! The Journal of Clinical Investigation. 2012; 122(2): 486-9.
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8. Cypess AM, Lehman S, Williams G, et al. Identification and Importance of Brown Adipose Tissue in Adult Humans. N Engl J Med. 2009; 360(15): 1509–1517.
9. Gouveia L, Coutinho C, Mendonça E. Functional biscuits with PUFA-ω3 from Isochrysis galbana. J Sci Food Agric. 2008; 88:891–896.
D0 D5
10. Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nature Medicine. 2013; 19(10): 1252-1263.
11. Kruglikov I. The Pathophysiology of Cellulite: Can the Puzzle Eventually Be Solved?*Journal of Cosmetics, Dermatological Sciences and Applications. 2012; 2:1-7.
12 Rosens ED, Spiegelman BM. What We Talk About When We Talk About Fat. Cell. 2014, 156(1):20-44.
Figure 11: Thermographic images obtained before (D0) and after 2 months (D56) of treatment with the active. The upper panel shows the abdominal area of a male volunteer, the middle panel shows the back of a female volunteer and the lower panel shows the front of a female volunteer.
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13. Rosenwald M, Perdikari A, Rülicke T, et al. Bi-directional interconversion of brite and white adipocytes. Nature Cell Biology. 2013; 15:659-667.
September 2021 PERSONAL CARE
DAY 56
DAY 28
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