HAIR CARE
Reishi offers hair health and growth efficacy
Melania Di Liberto, Roberta Donadelli, Guido Rovesti - CR&D S.r.l. Italy Fabrizio Gelmini, Giangiacomo Beretta - University of Milan, Italy
Ganoderma lucidum (Fr.) Karst (G. lucidum) is an oriental fungus belonging to the Ganodermaceae family from Polyporales. Also known as Reishi or Lingzhi in Japan and China, G. lucidum can be found in nature as a saprophyte or facultative parasite growing on the dead wood of deciduous species, in high humidity habitats of subtropical and temperate zones of Asia, Europe and North and South America. Already classified 2400 years ago by the
herbalist Shen Nong from the Shu Dynasty as the “superior herb”, G. lucidum is widely used in traditional Chinese medicine as an immune stimulant for promoting health, and for the prevention or the treatment of numerous diseases, such as bronchitis, chronic hepatitis, nephritis and high blood pressure.1 Among the over 2000 classes of Reishi
known to date, Shen Nong classified six different types of Ganoderma: red, purple, green, black and white. The red type (G. lucidum), due to the potential of its over
400 bioactive compounds, is known also as “the mushroom of immortality”. The fingerprinting of G. lucidum, already
reported in the most recent literature, includes triterpenoids, polysaccharides, sterols, steroids, amino acids and proteins,1
useful in literature for the treatment of: chronic hepatitis,2
atherosclerosis,3 blood pressure,5 diabetes,4
proved high
and anticancer potentialities.6
Between these classes, polysaccharides and triterpenoids were intensely investigated as responsible for the most relevant pharmacological and nutraceutical effects (i.e. anti-tumour, anti-angiogenic, anti-HIV, anti-hepatotoxic, anti-5-α reductase, anti- angiogenesis, anti-histaminic, cell protection from free radicals and peroxidation, body weight control, Fig 1). Interestingly, the cosmetic potential and applications of G. lucidum extracts, marketed primarily as a food complement (estimated global market: 2.16 billion dollar/year), have not yet been investigated.
However, in consideration of 1) the
demonstrated activities of ganoderic acids and polysaccharides on 5-α-reductase reduction and protein synthesis stimulation, and 2) the involvement of increased 5-α-reductase activity and decreased elastin synthesis in hair loss, the aim of this work was to propose a new registered cosmetic formula, Ganother®, which starting from Ganoderma Lucidum dried powder, Mycelium Ferment Filtrate, obtained by internal procedures, exploited the reported activities for a new application in the trichological field.
A new cosmetic formulation with significative trichological activities Ganother (now referred to as ‘Mycelium Ferment Filtrate‘) whose content in ganoderic acids has been evaluated at 1.22% (GC-MS analysis), was then subjected to a series of tests in order to verify its biological activity: first of all, the antioxidant activity evaluation (Folin- Ciocalteau assay7
), showed a good antioxidant
71
Pharmacological and nutraceutical effects
GANOTHER®
Polysaccharides
Triterpenes
· Immunostimulatory · Antiviral activity · Antioxidant · Antitumor · Body weight control
· Antioxidant · Antimicrobial · Anti HIV
Figure 1: Ganother ® - Pharmacological and nutraceutical effects related to the specific active compounds.
www.personalcaremagazine.com January 2021 PERSONAL CARE
· Anti histaminic · Anti 5a-reductase · Anti angiogenic
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