48 SKIN MICROBIOME
demonstrated the ability of the active ingredient to increase the tolerance of sensitive skin with a pre-treatment of three weeks.
The active strengthens the sensitive
skin by reducing the exaggerated response to external aggressions as shown in the trial. There was a reduction of increase in redness by 25% compared to placebo after applying an irritating patch. During the pre- treatment of just three weeks, the sensitive skin demonstrates a greater tolerance and a significant reduction in redness formation (Fig 2).
In vivo 2: Evaluation of erythema reduction and hydration Unlike in vivo 1, where a pre-treatment was used, the in vivo 2 analyses the post- treatment and immediate effect of the active on sensitive skin that has been irritated with the application of a patch. The active ingredient demonstrated the
ability to effectively reduce the generation of redness (Fig 3) with an erythema reduction by 18% and 19% after 1 and 24h from T1 where there was an induced irritation (1h after patch removal) compared to placebo. Also, a decrease of dehydration of sensitive skin with a TEWL reduction by 28% and 32% after 1 and 24h from T1 (1h after patch removal), compared to placebo was shown (Fig 4). Those values in both cases showed a
statistically significant difference with placebo, demonstrating the high activity of the active ingredient at only 1% concentration.
Conclusion The active ingredient Sensia Carota calms and protects sensitive skin, balancing inflammatory processes in the deepest skin layers and achieving a high moisturising effect. Through its mechanism of action, especially
tested on delicate and irritated skin, the active naturally rebalances the skin microbiota, keeps it in homeostasis, and produces a calming effect through the skin pleasure molecules. The cosmetic market presents a wide
variety of formulas in which the active ingredient has a direct application: refreshing lotions and gels, treatments that respect the skin microbiota, skin repairing and protective formulations, as well as natural and clean cosmetic products. This new raw material based on carrot
stem cells represents a new approach in the treatment of sensitive skin, in a way that respects the skin microbiota. A hopeful treatment in the middle of a global pandemic that impacts everyone, where cosmetic science may play a key role.
References 1 Rotter M. Hand washing and hand disinfection. In: Mayhall CG, editor. Hospital epidemiology and infection control. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1999, 1339–1355.
2 de Haan P, Meester HHM, Bruynzeel DP. Irritancy of alcohols. In: Van der Valk P, Maibach H, Eds. The irritant contact dermatitis syndrome. New York, NY: CRC Press; 1996, 65–70
PERSONAL CARE January 2021 treatment PRE * p<0.01
6 5 4 3 2 1
0 Non-treated skin Figure 2: Clinical evaluation of erythema prevention. 0 -5 treatment POST
-10 -15
-20 -25
-18% -19% Placebo cream ■ Cream with 1% SENSIA CAROTA■
After patch removal
1h after patch removal
24h after patch removal
1h ** 24h ***
Placebo cream
Cream with 1% SENSIA CAROTA
-25%
Figure 3: Clinical evaluation of erythema reduction. 0 treatment PC
hydration effect
Skin POST -5
-10 -15
-20 -25 -30 -35
1h *** 24h **
* p<0.001 ** p<0.01
-28% -32% Placebo cream ■ Cream with 1% SENSIA CAROTA■ Figure 4: Clinical evaluation of high skin hydration effect of the active.
www.personalcaremagazine.com
SENSIA CAROTA PLACEBO CREAM
TEWL reduction vs patch removal a* parameter variation
Erythema reduction vs patch removal
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