58 HYGIENE
Volunteer 3 before treatment
Volunteer 3 after treatment
Volunteer 4 before 4 week treatment
New study – Can a hand sanitiser combine hygiene and care properties? Study rationale Given Saccharide Isomerate’s proven skin barrier strengthening and moisturisation properties, DSM’s scientists decided to evaluate its efficacy when added as a moisturiser to a hand sanitiser formula containing 70% ethanol. The rationale for the study was that hand sanitisers need these high ethanol concentrations to be effective, but regular use of such products results in dry skin conditions. There is therefore a clear need for new, optimised formulas that can deliver appropriate safety in terms of protecting against viruses while also hydrating the skin.
Study design The study compared the moisturising efficacy and safety of a test product, in the form of a hand sanitiser containing 1% Saccharide Isomerate, with a base hand sanitiser formula (the placebo) on the skin of 10 healthy, Chinese adult females. Three days before testing began, study
Volunteer 4 after 4 week treatment Figure 2: Photographic images of the visible improvement in dry skin in two volunteers after four weeks of treatment with Pentavitin.
volunteers were asked to cleanse both their forearms with water only and not to apply any other cosmetics or medicines to the area. During the study, performed March 2020
in Beijing, volunteers applied both test products to their inner forearms. There were three test sites, each of about 4cm x 5cm – a randomised scheme was used to apply the two test products and there was also an untreated control on these test sites. The test environmental conditions were 21 ± 1°C temperature and 50 ± 5% relative humidity. Corneometer readings were taken at the baseline and at one hour and three hours after applying test products. An average of three capacitance measurements were taken for each test site. Safety and adverse effects were assessed through clinical evaluation by a dermatologist and volunteer feedback in the form of a questionnaire.
Study findings demonstrate enhanced skin hydration in a hand sanitiser For the statistical model, the percentage change in skin hydration from three groups (untreated, placebo, Saccharide Isomerate) was analysed
TABLE 1: MEAN + SEM CAPACITANCE VALUES ON FOREARM BEFORE TREATMENT (BASELINE) AND AFTER TREATMENT (1 HOUR AND 3 HOURS).
Untreated Placebo formula
PENTAVITIN® formula p=0.007
0 hours (baseline) 32.85 ± 1.31 33.67 ± 0.96
31.56 ± 1.24 PERSONAL CARE January 2021 1 hours
31.47 ± 1.44 34.76 ± 0.83
35.36 ± 1.24 3 hours
29.95 ± 1.53 29.71 ± 1.53
31.91 ± 1.27
using an ANCOVA model with treatment as a factor and the baseline skin hydration value as a covariate. The demographic and baseline hydration
characteristics of the randomised population were similar across the three groups (untreated, placebo, Saccharide Isomerate). Skin hydration data for the three groups
is shown in Table 1 in the form of mean capacitance values as measured directly in the 10 test subjects. After treatment, skin hydration in both the placebo group and the Saccharide Isomerate group increased after one hour and decreased between one and three hours, whereas in the blank control group, skin hydration decreased slightly throughout the test period. Overall, the Saccharide Isomerate formula retained moisture levels most effectively after treatment. The graph in Figure 3 visualises these
capacitance values normalised to the untreated group and set to 100%. It shows that after three hours, hydration levels for the placebo were at 96.8%, which was drier than in untreated skin, whereas for Saccharide Isomerate, hydration levels were at 110.9%, indicating better hydration than in untreated skin. The study results demonstrate therefore that the sanitiser containing 1% Saccharide Isomerate boosted hydration by 9% more than the placebo just one hour after application and by 14% more than the placebo after three hours. The results also confirm that skin dryness develops within three hours of applying a standard hand sanitiser once. Moreover, this
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