SKIN MICROBIOME 69
First Cannabis sativastem cells: nourishing microbiota
n Ò. Expósito, A. Guirado, D. Robustillo, A. Gallego, M. Mas, P. Riera, D. Luna, S. Laplana, T. Ruiz, S. Ruiz - Vytrus Biotech, Spain
The skin is a mirror of your emotional state and internal conflicts because it is linked to the nervous system since its embryonic development.1 The latest literature describes the skin as
the third brain or as the new neuroendocrine organ. It has been demonstrated that cutaneous cells are able to synthesise a plethora of endocrine neurochemicals like dopamine, oxytocin, endorphins, histamine, serotonin, adrenaline.2-7 The role of the brain includes reception,
processing, and transmission of environmental information from sensory organs to the systems of the whole body. The digestive organs have an independent nervous system (‘second brain’). We propose that the skin, which forms the interface between the body and the environment, could be considered our ‘third brain’. The skin contains multiple environmental
sensors and a sensory information- processing system, which generates a variety of hormones and neurotransmitters with the potential to influence whole-body states and emotions. Cultured human keratinocytes can
generate endocrine neurochemicals. These results are consistent with the hypothesis that the epidermis plays a significant role in adapting whole-body physiology and emotional response to changing environments. The skin could be considered an
Abstract
The skin microbiota and the brain are connected through an existing natural pathway where the microbiota is the first step. The new active Kannabia SensePLF
(INCI name:
Cannabis Sativa Callus Lysate), is the first generation of Cannabis sativa plant stem cells and introduces the concept of in situ postbiotic. Through its mechanism of action, the active modulates the skin commensal microbiota to produce a positive in situ postbiotic cocktail that ignites the synthesis of happiness related neurochemicals from the skin that connects with the brain, turning into a wellbeing response and a healthier and stronger skin. Several in vitro and in vivo trials have been carried out to demonstrate the skin well-ageing effect, positive brain activation and modulation of mood state thanks to the active ingredient.
Figure 1: Microbiota-skin-brain axis.
expanded brain sensory organ. In addition to the classic senses (touch, taste, smell, sight and hearing), the skin has a great diversity of ‘other sensory capabilities’ as well as a huge surface of interaction with the environment that helps the brain analyse and adapt better to changing environmental conditions. The skin is proposed here as a social
organ since their neuroendocrine sensorial abilities play a very important role in social perception.
The skin-brain axis is vertebrate through
the neuroendocrine system capable of producing signalling molecules at local and systemic level that act as a connection platform between the skin and brain. We could also add the social dimension to the skin-brain equation.
The microbiota-skin-brain axis The skin is a neuroendocrine organ able to synthesise a plethora of neuropeptides and neurotransmitters such as oxytocin, serotonin, β-endorphin, etc. The microbiota is the most superficial
layer of the skin and has much more metabolisation potential than human cells. In fact, this microbiota gives our skin cells an increased metabolism capacity to perceive and manage all information that comes from the environment and within the body. Microbiota can interfere in the skin
Figure 2: Analysis of the Microbiota-Skin-Brain axis networks. November 2020
neurochemical networks and enhance the production of wellbeing-linked molecules like oxytocin (the happiness hormone) by the synthesis of an in situ postbiotic cocktail. The skin microbiota can metabolise a
PERSONAL CARE ASIA PACIFIC
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