ANTI-AGEING 63


Tripeptide complex for a range of anti-ageing targets


n Peter Jung – Equipforskin, South Korea


A topically applicable new tripeptide complex shows promising in vitro results as anti-ageing cosmetic and cosmeceutical ingredients against a variety of ageing factors.


Skin ageing Skin ageing is a complex process caused by both intrinsic and extrinsic factors and progressively losing the structure and function of the skin. Oxidative stress induced by reactive oxygen species (ROS) plays an important role in the process of human skin ageing, especially at the subcutaneous layer. Extrinsic skin ageing is driven mainly by environmental factors and external stresses such as ultraviolet radiation (UVR), pollution and lifestyle factors that also stimulate the production of ROS and generate oxidative stress. Skin ageing is also a kind of


inflammation process caused by a variety of


intrinsic and extrinsic factors since various inflammatory cytokines are involved in the middle of the ageing mechanism.


Natural vs. synthetic peptides and polypeptides vs. tripeptides Natural human peptides are known to be involved in immunity, stress, homeostasis and reproduction through cellular communication or signalling like protein regulation, cell proliferation, inflammation and melanogenesis. Likewise, many short, stable and functional synthetic peptides have also been developed by scientists and industry. Dr. JH Hahn, a biomimetic scientist and professor with over 30 years of experience, has confirmed no functional difference between 3-4 amino acid peptides and the 10-50 amino acid polypeptides and developed lots of patented functional tripeptides for


pharmaceutical, cosmeceutical and cosmetic use.


The anti-ageing tripeptide complexes ‘Dr Hahn antiaging tripeptide complex I & II’ (Antiagin R I, II) consist of 2 or 4 of less than 500 Da. topically applicable functional tripeptides, such as AdiponinTM


name: Acetyl Tripeptide-74 Amide), SynepinTM


Acetyl Tripeptide-54 Amide), EnfibinTM (INCI name: Palmitoyl


sh-Tripeptide-3 Amide) and SynderminTM (INCI name: Palmitoyl sh-Tripeptide-1 Amide). Adiponin, as an adipose (fat) derived tripeptide, forms a skin barrier and protects the skin from inflammatory mechanisms by UVB and pollution. Enfibin blocks NFkB, a transcription factor to induce inflammatory ageing. Synpin is an epidermal growth factor tripeptide and Syndermin is a fibroblast growth factor


(INCI name: (INCI


Figure 1: Effect of Adiponin: When applied with AdiponinTM August 2020


, essential molecules for skin barrier formation were increased and fibroblast, collagen, elastin and HA were also proliferated. PERSONAL CARE GLOBAL


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84